Full Text PA-95-049

MENTORED RESEARCH SCIENTIST DEVELOPMENT AWARD

NIH GUIDE, Volume 24, Number 15, April 28, 1995

PA NUMBER:  PA-95-049

P.T. 34

Keywords: 
  Biomedical Research, Multidiscipl 


National Institute on Aging
National Institute on Alcohol Abuse and Alcoholism
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Cancer Institute
National Institute of Environmental Health Sciences
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
National Institute of Nursing Research
National Center for Human Genome Research
National Center for Research Resources

Application Receipt Dates:  February 1, June 1, and October 1

PURPOSE

The Mentored Research Scientist Development Award (MRSDA) is for
research scientists who need an additional period of sponsored
research experience as a way to gain expertise in a research area new
to the candidate or in an area that would demonstrably enhance the
candidate's scientific career.  It is expected that following this
experience, the candidate will be able to pursue an independent and
productive research career.

The Mentored Research Scientist Development Award (K01) provides an
intensive, supervised career development experience in one of the
biomedical, behavioral, or clinical sciences.  The proposed
experience should be in a research area new to the applicant and/or
one in which an additional supervised research experience will
demonstrably enhance the candidate's scientific career.  The
experiences should permit the application of novel or highly
promising interdisciplinary approaches to particular research
problems.  Candidates must justify the need for a three, four, or
five year period of mentored research experience and must be able to
provide a convincing case that the proposed period of support will
substantially enhance his/her career and/or will allow the pursuit of
a novel or promising approach to a particular research problem.

Candidates who have interrupted their careers because of illness or
pressing family care commitments may apply if they can clearly
demonstrate the potential for productive independent research and the
need for an additional period of mentored research experience in
order to accomplish an effective scientific reentry.

Similarly, faculty members at institutions with a substantial
minority enrollment, who wish to enhance their research skills
through a supervised research experience at a nearby research center,
may also apply, if they agree to remain at their parent institution
after completion of the award.

The MRSDA replaces four existing NIH career development mechanisms,
including the Research Scientist Development Award (K01), the
Minority School Faculty Development Award (K14), the Research Career
Reentry Program (K17), and the Scientist Development Award (K21).
Individuals who were eligible to apply for any one of these awards
are now eligible to apply for a K01 award.  Therefore, this Program
Announcement (PA) supersedes all previous K01, K14, K17, and K21
program announcements.

The NIH will no longer accept competing applications for the old K01,
K14, K17, and K21 awards.  Existing policies and provisions will
remain in effect for current K01, K14, K17, and K21 recipients until
completion of the non-competing years of their three to five year
career development program.

Funding institutes and centers may, from time to time, issue PAs or
requests for applications (RFAs) that modify the ELIGIBILITY
REQUIREMENTS or MECHANISM OF SUPPORT sections of this program
announcement in order to meet special program needs such as
soliciting applications from specially targeted groups of
investigators.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This PA,
Mentored Research Scientist Development Award, is related to the
priority area of human resource development.  Potential applicants
may obtain a copy of "Healthy People 2000" (Full Report:  Stock No.
017-001-00474-0 or Summary Report:  Stock No. 017-001-00473-1) from
the Superintendent of Documents, Government Printing Office,
Washington, DC 20402-9325 (telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

In general, the candidate must have a research or a health-
professional doctorate or its equivalent, and must have demonstrated
the capacity or potential for highly productive independent research
in the period after the doctorate.  Applicants for the K01 from the
National Center for Human Genome Research, however, may be non-
biologists without a doctoral degree such as computer scientists,
physicists, mathematicians, and chemists.  All applicants are
encouraged to contact the prospective NIH awarding component
regarding their eligibility for the K01.

The candidate must identify a mentor with extensive research
experience, and must be willing to spend a minimum of 75 percent of
full-time professional effort conducting research and research career
development activities for the period of the award.

Applications may be submitted on behalf of candidates by domestic,
non-Federal organizations, public or private, such as medical,
dental, or nursing schools or other institutions of higher education.
Minorities and women are encouraged to apply.  Candidates must be
U.S. citizens or noncitizen nationals, or must have been lawfully
admitted for permanent residence and possess an Alien Registration
Receipt Card (I-151 or I-551) or some other verification of legal
admission as a permanent resident.  Noncitizen nationals, although
not U.S. citizens, owe permanent allegiance to the U.S.  They are
usually born in lands that are not states, but are under U.S.
sovereignty, jurisdiction, or administration.  Individuals on
temporary or student visas are not eligible.

Candidates may have been principal investigators on PHS research
grants and may have been supported by a research career award in the
past, provided the proposed research experience is a fundamentally
new field of study or there has be a significant hiatus in their
research career because of family or other personal obligations.
Current principal investigators on PHS research grants are not
eligible.

MECHANISM OF SUPPORT

Awards in response to this PA will use the K01 mechanism.  Planning,
direction, and execution of the program will be the responsibility of
the candidate and her/his mentor on behalf of the applicant
institution.  The project period may be for three, four, or five
years and will depend upon the number of years of prior research
experience, the need for additional experiences to achieve
independence, and the policy of each particular institute or center.
Awards are not renewable.

RESEARCH OBJECTIVES

A.  Environment:  The institution must have a well-established
research and/or clinical career development program(s) and qualified
faculty to serve as mentors.  The institution must be able to
demonstrate a commitment to the development of the candidate as a
productive, independent investigator.  And, the candidate, mentor and
institution must be able to describe a multi- disciplinary career
development program that will maximize the use of relevant research
and educational resources.

B.  Program:  The award provides three to five consecutive 12 month
appointments.  At least 75 percent of the recipient's full-time
professional effort must be devoted to the program and the remainder
devoted to other research-related and/or teaching pursuits consistent
with the objectives of the award.  The candidate must develop
knowledge in the basic sciences and research skills relevant to his
or her career goals.  The candidate may find it appropriate to
include relevant didactic and laboratory or field research
experiences.

C.  Mentor(s):  The recipient must receive appropriate mentoring
throughout the three to five year program.  Where feasible, women and
minority mentors should be involved as role models.

D.  Allowable Costs:

1.  Salary:  The NIH will provide salary and fringe benefits for the
K award recipient.  The salary limits are not uniform throughout the
NIH and are determined independently by each component of the NIH.
Therefore, prospective candidates should contact the NIH component to
which the application is targeted to ascertain the maximum
contribution to the candidate's salary.

The institution may supplement the NIH contribution up to a level
that is consistent with the institution's salary scale; however,
supplementation may not be from Federal funds unless specifically
authorized by the Federal program from which such funds are derived.
In no case, may PHS funds be used for salary supplementation.
Institutional supplementation of salary must not require extra duties
or responsibilities that would interfere with the purpose of the
MRSDA.  Under expanded authorities, however, institutions may
rebudget funds within the total costs awarded to cover salaries
consistent with the institution's salary scale.

The total salary requested must be based on a full-time, 12-month
staff appointment.  It must be consistent both with the established
salary structure at the institution and with salaries actually
provided by the institution from its own funds to other staff members
of equivalent qualifications, rank, and responsibilities in the
department concerned.  If full-time, 12-month salaries are not
currently paid to comparable staff members, the salary proposed must
be appropriately related to the existing salary structure.

2.  Research Development Support:  Most awarding components of the
NIH will provide up to $20,000 per year for the following expenses:
(a) tuition, fees, and books related to career development; (b)
research expenses, such as supplies, equipment, and technical
personnel; (c) travel to research meetings or training; (d)
statistical services including personnel and computer time.  The
National Institute of Mental Health will provide up to $50,000 for
research development support.

3.  Ancillary Personnel Support:  Salary for mentors, secretarial and
administrative assistance, etc., is not allowed.

4.  Indirect costs:  Indirect costs will be reimbursed at eight
percent of modified total direct costs, or at the actual indirect
cost rate, whichever is less.

F.  Evaluation:  In carrying out its stewardship of human resource
related programs, the NIH may begin requesting information essential
to an assessment of the effectiveness of this program.  Accordingly,
recipients are hereby notified that they may be contacted after the
completion of this award for periodic updates on various aspects of
their employment history, publications, support from research grants
or contracts, honors and awards, professional activities, and other
information helpful in evaluating the impact of the program.

G.  Other Income:  Fees resulting from clinical practice,
professional consultation, or other comparable activities required by
the research and research-related activities of this award may not be
retained by the career award recipient.  Such fees must be assigned
to the grantee institution for disposition by any of the following
methods:

The funds may be expended by the grantee institution in accordance
with the NIH policy on supplementation of career award salaries and
to provide fringe benefits in proportion to such supplementation.
Such salary supplementation and fringe benefit payments must be
within the established policies of the grantee institution.

The funds may be used for health-related research purposes.

The funds may be paid to miscellaneous receipts of the U.S. Treasury.
Checks must be made payable to the Department of Health and Human
Services, NIH and forwarded to the Director, Division of Financial
Management, NIH, Bethesda, Maryland 20892.  Checks must identify the
relevant award account and reason for the payment.

Awardees may retain royalties and fees for activities such as
scholarly writing, service on advisory groups, or honoraria from
other institutions for lectures or seminars, provided these
activities remain incidental and provided that the retention of such
pay is consistent with the policies and practices of the grantee
institution.

Usually, funds budgeted in an NIH supported research or research
training grant for the salaries or fringe benefits of individuals,
but freed as a result of a career award, may not be rebudgeted.  The
awarding component will give consideration to approval for the use of
released funds only under unusual circumstances.  Any proposed
retention of funds released as a result of a career award must
receive prior written approval of the NIH awarding component.

H.  Special Leave:  Leave to another institution, including a foreign
laboratory, may be permitted if directly related to the purpose of
the award.  Only local, institutional approval is required if such
leave does not exceed three months.  For longer periods, prior
written approval of the NIH funding component is required.  To obtain
prior approval, the award recipient must submit a letter to the NIH
describing the plan, countersigned by his or her department head and
the appropriate institutional official.  A copy of a letter or other
evidence from the institution where the leave is to be taken must be
submitted to assure that satisfactory arrangements have been made.
Support from the career award will continue during such leave.

Leave without award support may not exceed 12 months.  Such leave
requires the prior written approval of the NIH funding component and
will be granted only in unusual situations.  Support from other
sources is permissible during the period of leave.  Such leave does
not reduce the total number of months of program support for which an
individual is eligible.  Parental leave will be granted consistent
with the policies of the NIH and the grantee institution.

I.  Termination or Change of Institution:  When a grantee institution
plans to terminate an award, the NIH funding component must be
notified in writing at the earliest possible time so that appropriate
instructions can be given for termination.  If the individual is
moving to another eligible institution, career award support may be
continued provided:

A new career award application is submitted by the new institution;

The period of support requested is no more than the time remaining
within the existing award period; and

The new application is submitted far enough in advance of the
requested effective date to allow the necessary time for review.

The funding component may require a review by an initial review group
and/or the appropriate National Advisory Council or Board.
Alternatively, review may be carried out by staff within the NIH
funding component, depending upon the circumstances.

The Director of the NIH may discontinue an award upon determination
that the purpose or terms of the award are not being fulfilled.  In
the event an award is terminated, the Director of the NIH shall
notify the grantee institution and career award recipient in writing
of this determination, the reasons therefor, the effective date, and
the right to appeal the decision.

A final progress report, invention statement, and Financial Status
Report are required upon either termination of an award or
relinquishment of an award in a change of institution situation.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN
SUBJECTS

It is the policy of the NIH that women and members of minority groups
and their subpopulations must be included in all NIH supported
biomedical and behavioral research projects involving human subjects,
unless a clear and compelling rationale and justification is provided
that inclusion is inappropriate with respect to the health of the
subjects or the purpose of the research.  This new policy results
from the NIH Revitalization Act of 1993 (Section 492B of Public Law
103-43) and supersedes and strengthens the previous policies
(Concerning the Inclusion of Women in Study Populations, and
Concerning the Inclusion of Minorities in Study Populations) which
have been in effect since 1990.  The new policy contains some new
provisions that are substantially different from the 1990 policies.

All investigators proposing research involving human subjects should
read the "NIH Guidelines For Inclusion of Women and Minorities as
Subjects in Clinical Research," which have been published in the
Federal Register of March 28, 1994 (FR 59 14508-14513), and reprinted
in the NIH GUIDE FOR GRANTS AND CONTRACTS of March 18, 1994, Volume
23, Number 11.

Investigators may obtain copies from these sources or from the
program staff or contact person listed under INQUIRIES.  Program
staff may also provide additional relevant information concerning the
policy.

APPLICATION PROCEDURES

This is a generic program announcement for the MRSDA.  Because some
of the NIH institutes and centers may not participate in this program
or may have different award provisions, it is strongly recommended
that prospective applicants contact the staff person in the relevant
institute or center listed under INQUIRIES early in the planning
phase of application preparation.  Such contact will help ensure that
applications are responsive to the career development goals and
policies of the NIH institute or center.

Applications are to be submitted on form PHS 398 (rev. 9/91) and will
be accepted on or before the receipt deadlines indicated in the
application kit (February 1, June 1 and October 1).  Forms are
available at most institutional offices of sponsored research and
from the Office of Grants Information, Division of Research Grants,
NIH, 5333 Westbard Avenue, Room 449, Bethesda, MD 20892, telephone
301/435-0714.

The application must address the following issues:

Candidate

o  Establish the candidate's commitment to a career in biomedical or
behavioral research

o  Establish the candidate's potential to develop into a successful
independent investigator.

o  Summarize the candidate's immediate and long-term career
objectives, explaining how the award will contribute to their
attainment.

o  Letters of recommendation.  Three sealed letters of recommendation
addressing the candidate's potential for a research career must be
included as part of the application

Career Development Plan

o  Describe the career development plan, incorporating consideration
of the candidate's goals and prior experience.  It should describe a
systematic plan to obtain the necessary basic biomedical or
behavioral science background and research experience to launch or
reinitiate an independent research career.

o  Candidates must describe plans to receive instruction in the
responsible conduct of research.  These plans must detail the
proposed subject matter, format, frequency, and duration of
instruction as well as the amount and nature of faculty
participation.  No award will be made if an application lacks this
component.

Research Plan

o  Describe the research plan and the use of a basic or clinical
approach to a biomedical or behavioral problem.  The candidate and
mentor together must describe the research plan as outlined in form
PHS 398 including sections on the  Specific Aims, Background and
Significance, Progress Report/Preliminary Studies, Research Design
and Methods.

Mentor's Statement

o  The application must include information on the mentor(s)
including information on  research qualifications and previous
experience as a research supervisor.  The application must also
include information that describes the nature and extent of
supervision that will occur during the proposed award period.

Environment and Institutional Commitment

o  The sponsoring institution must document a strong, well-
established research program related to the candidate's area of
interest including a high-quality research environment with staff
capable of productive collaboration with the candidate.  The
sponsoring institution also must provide a statement of commitment to
the candidate's development into a productive, independent
investigator.

Budget

o  Budget requests must be provided according to the instructions in
form PHS 398.  The request for tuition and fees, books, travel, etc.,
must be justified and specified by category.

To identify the application as a response to this PA, check "YES" on
item 2a of page 1 of the application and enter "PA-95-049, Mentored
Research Scientist Development Award" and the name of the NIH
institute or center that you would like the application to be
assigned for funding.

Submit a signed, typewritten original of the application with
Checklist, and five signed photocopies, in one package to:

Division of Research Grants
National Institutes of Health
6701 Rockledge Drive, Room 1040  MSC 7710
Bethesda, MD  20892-7710
Bethesda, MD  20817 (for express/courier service)

REVIEW CONSIDERATIONS

Applications will be reviewed for completeness by the Division of
Research Grants and responsiveness to the PA by the appropriate
institute or center staff.  Applications that are complete and
responsive to the program announcement will be evaluated for
scientific and technical merit by an appropriate peer review group
convened in accordance with the standard NIH peer review procedures.
As part of the initial merit review, all applications will receive a
written critique and undergo a process in which only those
applications deemed to have the highest scientific merit, generally
the top half of applications under review, will be discussed,
assigned a priority score, and receive a second level review by he
appropriate national advisory council or board.

The following review criteria will be applied:

Candidate

o  Commitment to an independent research career;

o  Potential to develop (or evidence of the capacity to develop) as
an independent investigator;

o  Quality and breadth of prior scientific training and experience,
including, where appropriate, the record of previous research support
and publications.

Career Development Plan

o  Likelihood that the plan will contribute substantially to the
scientific development of the candidate and the achievement of
scientific independence;

o  Appropriateness of the research plan to the career goals of the
candidate;

o  Appropriateness of the plan to update conceptual and theoretical
knowledge, and the proposed award duration;

o  Consistency of the career development plan with the candidate's
prior research and academic experience and the stated career goals;

o  Clarity of the goals and scope of the plan and the need for the
proposed research experience; and

o  Quality of the proposed training in the responsible conduct of
research.

Research Plan

All candidates for this award will have had previous research
experience and in some cases will have been Principal Investigators
in other scientific fields.  A sound research plan that is consistent
with the career development plan and the candidate's level of
research development must be provided.

o  Usefulness of the research plan as a vehicle for enhancing
existing research skills as described in the career development plan;

o  Scientific and technical merit of the research question, design
and methodology, judged in the context of the candidate's previous
training and experience;

o  Relevance of the proposed research to the candidate's career
objectives; and

o  adequacy of plans to include both genders and minorities and their
subgroups as appropriate for the scientific goals of the research.
Plans for the recruitment and retention of subjects will also be
evaluated.

Mentor

o  Appropriateness of mentor's research qualifications in the area of
this application;

o  Quality and commitment of the mentor to supervising and guiding
the candidate throughout the award period;

o  Previous experience in fostering the development of researchers;
and

o  History of research productivity and support.

Institutional Environment and Commitment

o  Applicant institution's commitment to the scientific development
of the candidate and assurances that the institution intends the
candidate to be an integral part of its research program;

o  Adequacy of research facilities and training opportunities;

o  Quality of environment for scientific and professional
development; and

o  Applicant institution's willingness to develop an appropriate mix
of research, teaching and administrative responsibilities for the
candidate.

Budget

o  Justification of budget requests in relation to career development
goals and research aims and plans.

AWARD CRITERIA

The NIH institute or center will notify the applicant of the national
advisory board or council's action shortly after its meeting.
Funding decisions will be made based on the recommendations of the
initial review group and council/board, the need for research
personnel in specific program areas, and the availability of funds.

INQUIRIES

Written and telephone inquiries concerning this PA are encouraged,
especially during the planning phase of the application.  Below is a
listing of each institute's or center's program or grants management
contacts.

Dr. Robin A. Barr
Office of Extramural Affairs
National Institute on Aging
Gateway Building, Room 2C218, MSC 9205
7201 Wisconsin Avenue
Bethesda, MD  20892-9205
Telephone:  (301) 496-9322
FAX:  (301) 402-9245
Email:  Barr@nihniagw.bitnet

Dr. Ernestine D. Vanderveen, Ph.D.
Division of Basic Research
National Institute on Alcohol Abuse and Alcoholism
6000 Executive Boulevard, Suite 402 MSC 7003
Bethesda, MD  20892-7003
Telephone:  (301) 443-1273
FAX:  (301) 594-0673
Email:  tvanderv@willco.niaaa.nih.gov

Ms. Frances Cotter
Division of Clinical and Prevention Research
National Institute on Alcohol Abuse and Alcoholism
6000 Executive Boulevard, Suite 505 MSC 7003
Bethesda, MD  20892-7003
Telephone:  (301) 443-1207
FAX:  (301) 443-8744
Email:  fcotter@willco.niaaa.nih.gov

Dr. Mary C. Dufour
Division of Biometry and Epidemiology
National Institute on Alcohol Abuse and Alcoholism
6000 Executive Boulevard, Suite 514 MSC 7003
Bethesda, MD  20892-7003
Telephone:  (301) 443-4897
FAX:  (301) 443-8614
Email:  m.dufour@willco.niaaa.nih.gov

Richard Lymn, Ph.D.
Extramural Programs
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Natcher Building, Room 5AS-49E
45 Center Drive, MSC 6500
Bethesda, MD  20892-6500
Telephone:  (301) 594-5128
FAX:  (301) 480-4543
Email:  rl28b@nih.gov

The NICHD will accept applications for the K01 under Clinical
Rehabilitation Investigator Development Award (CRIDA), but will limit
eligibility to candidates who have both clinical training in the
rehabilitation related professions (e.g., P.T., O.T., R.N.) and
possess doctoral level degrees (e.g., Ph.D., D.Eng., D.Ed.).
Individuals supported under CRIDA must be committed to developing
careers as independent investigators in medical rehabilitation.

Danuta Krotoski, Ph.D.
National Center for Medical Rehabilitation Research
National Institute of Child Health and Human Development Building
61E, Room 2A03
Bethesda, MD  20892-7510
Telephone:  (301) 402-2242
FAX:  (301) 402-0832
Email:  krotoskd@hd01.nichd.nih.gov

Dr. Lester Gorelic
Division of Extramural Activities
National Cancer Institute
Executive Plaza North, Room 643
Bethesda, MD  20892
Telephone:  (301) 496-7344
FAX:  (301) 402-4551
Email:  gorelicl@dea.nci.nih.gov
(This award is reserved exclusively for minority faculty development)

Dr. Michael Galvin
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233, MD 3-02
Research Triangle Park, NC  27709
Telephone:  (919) 541-7825
FAX:  (919) 541-2843
Email: galvin@niehs.nih.gov

National Heart, Lung, and Blood Institute

(The NHLBI does not accept applications for the Mentored Research
Scientist Award (K01).  It does, however, periodically issue Request
for Applications (RFA) for the Minority School Faculty Development
Award (K01) and the Research Development Award for Minority Faculty
(K01) in the NIH Guide for Grants and Contracts.)

Dr. Bettie Graham
National Center for Human Genome Research
Building 38A, Room 610
Bethesda, MD  20892
Telephone:  (301) 496-7531
FAX:  (301) 480-2770
Email:  bg30t@nih.gov

George T. Niederehe, Ph.D.
Division of Clinical and Treatment Research
National Institute of Mental Health
5600 Fishers Lane, Room 18-105
Rockville, MD  20857
Telephone:  (301) 443-3264
FAX:  (301) 594-6784
Email:  gniedere@aoamh4.ssw.dhhs.gov

Kenneth G. Lutterman, Ph.D.
Division of Epidemiology and Services Research
National Institute of Mental Health
5600 Fishers Lane, Room 10-95
Rockville, MD  20857
Telephone:  (301) 443-3373
FAX:  (301) 443-4045
Email:  klutterm@nih.gov

Henry Khachaturian, Ph.D.
Division of Neuroscience and Behavioral Science
National Institute of Mental Health
5600 Fishers Lane, Room 11-103
Rockville, MD  20857
Telephone:  (301) 443-8033
FAX:  (301) 443-1731
Email:  hkhach@helix.nih.gov

Leonard Mitnick, Ph.D.
Office of AIDS Programs
National Institute of Mental Health
5600 Fishers Lane, Room 10-75
Rockville, MD  20857
Telephone:  (301) 443-9719
FAX:  (301) 443-9719
Email:  lmitnick@aoamh2.ssw.dhhs.gov

Mr. Edward Donohue
Division of Extramural Activities
National Institute of Neurological Disorders and Stroke Federal
Building, Room 1016A
Bethesda, MD  20892
Telephone:  (301) 496-4188
FAX:  (301) 402-4370
Email:  ed25b@nih.gov

Dr. Mary Lucas Leveck
Acute and Chronic Illness Branch
National Institute of Nursing Research
Building 45, Room 3AN-12
Bethesda, MD  20892-6300
Telephone:  (301) 594-5963
FAX:  (301) 480-8260
Email:  mleveck@ep.ninr.nih.gov

Leo A. Whitehair, D.V.M, Ph.D.
Comparative Medicine Program
National Center for Research Resources
Westwood Building, Room 857
Bethesda, MD  20892
Telephone:  (301) 435-0746
FAX:  (301) 480-3660
Email:  leow@ep.ncrr.nih.gov

AUTHORITY AND REGULATIONS

The Mentored Research Scientist Development Awards are made under the
authority of Title III, Section 301 of the Public Health Service
(PHS) Act as amended (Public Law 78-410, as amended, 42 USC 241).
The Code of Federal Regulations, Title 42 Part 52, and Title 45 part
74, are applicable to this program.  This program is described in the
Catalog of Federal Domestic Assistance No. 93.121.  This program is
not subject to the intergovernmental review requirements of Executive
Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to
provide a smoke-free workplace and promote the non-use of all tobacco
products.  In addition, Public Law 103-227, the Pro-Children Act of
1994, prohibits smoking in certain facilities (or in some cases, any
portion of a facility) in which regular or routing education,
library, day care, health care or early childhood development
services are provided to children.  This is consistent with the phs
mission to protect and advance the physical and mental health of the
american people.

.

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