Full Text PA-95-034 EVALUATION, TREATMENT, AND PROGNOSIS OF THE COMMUNICATION SEQUELAE OF TRAUMATIC BRAIN INJURY NIH GUIDE, Volume 24, Number 7, February 24, 1995 PA NUMBER: PA-95-034 P.T. 34 Keywords: Brain Injury Trauma Communicative Disorders, Speech Pathophysiology National Institute on Deafness and Other Communication Disorders PURPOSE Approximately 50,000 of the estimated two million people who suffer traumatic brain injury (TBI) each year in the United States have severe persisting communication problems as a result. Head injuries can occur at any time in life; however, they are the primary cause of mortality among Americans under the age of 34. Survival rates are particularly high for children who, along with young adults, constitute the age group at highest risk for head injury; and, with the increasing sophistication of early medical management, the rate of survival continues to improve. Although survival rates are high among both children and adults, recent studies have questioned the traditional belief that the prognosis for full recovery is better in children than in adults with comparable injuries. Little is known about the underlying neural damage or the pathophysiology of the speech production deficits and language disabilities commonly associated with traumatic brain injury. The National Institute on Deafness and Other Communication Disorders (NIDCD) of the National Institutes of Health (NIH) invites applications for the study of the voice, speech, and language sequelae of traumatic brain injury, with particular reference to pathophysiology, neuropathology, evaluation, treatment, and prognosis. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This program announcement, Evaluation, Treatment, and Prognosis of the Communication Sequelae of Traumatic Brain Injury, is related to the priority areas of diabetes and chronic disabling conditions and special population objectives. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-11474-0 or Summary Report: Stock No. 017-001-11473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign, for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the Federal government. Foreign institutions are not eligible for First Independent Research Support and Transition (FIRST) (R29) awards. Applications from minority individuals, women, and individuals with disabilities are encouraged. MECHANISM OF SUPPORT The support mechanisms for grants in this area will be the individual investigator-initiated research project grant (R01) and the FIRST (R29) award. RESEARCH OBJECTIVES Traumatic brain injury (TBI) is an unusual disability category in that virtually any central nervous system function can be either spared or impaired. In contrast to disability categories such as aphasia, mental retardation, or learning disability, it is difficult to predict the strengths, weaknesses, and outcomes of individuals who have sustained TBI. Outcome is influenced by many factors including pretraumatic characteristics (e.g., age, education, personality, communication skills), nature and severity of the injury, and posttraumatic factors (e.g., stage of recovery, medical and rehabilitative treatment, experience following the injury, support and emotional adjustment). Adults with TBI are different as a group from adults with other acquired neurogenic communication disorders such as aphasia secondary to stroke; they are predominantly young and their communication profiles rarely resemble classical aphasia syndromes. Their characteristic cognitive and behavioral challenges, often related to prefrontal and anterior temporal lobe structures, necessitate modifications of transitional assessment and intervention strategies. Furthermore, the early stages of recovery following severe TBI are often protracted and include a relatively predictable evolution of cognitive, communicative, and behavioral symptoms. Children with TBI represent a unique challenge to pediatric rehabilitation professionals and school clinicians because children with TBI, unlike those with congenital disorders, may improve neurologically for months or years after the injury and may recover much of the information and skills acquired before their injury despite substantial new learning and behavioral self-regulation problems. There are often delayed consequences of prefrontal injury in young children, necessitating long-term follow-up and flexibility in services for years after a severe injury. In addition, the profile of language strengths and weaknesses of children with TBI tend to be quite unlike those of children with specific language-learning disabilities or general developmental delay, and the emotional issues associated with loss of function are often different from those associated with developmental problems. Although the behavioral sequelae of head trauma are reportedly less severe in children than in adults, the presence, nature, and degree of deficits following head injury are so widely varied depending on severity, age of onset, and even the type of outcome assessment, that this general statement offers little in the way of meaningful information. Health professionals continue to be perplexed by individuals with TBI who remain as severely speech- and language-impaired ten years after injury as they were one year after injury. Nor is it understood why other individuals may show remarkable and continuing improvement even five years after injury. Equally puzzling are the varieties of voice, speech, language, and swallowing disorders that are manifest in various combinations within a given individual. There is little published data regarding the speech and language deficits and related pathophysiology following traumatic brain injury. The limited research available identifies three areas of speech production deficit: initiation, dyspraxia, and dysarthria. Persistent aphonia after mutism is reported in patients who are recovering from severe traumatic brain injury, and documentation of the behavioral, neuropsychological, and language sequelae of head trauma has begun. Information gained from research in these areas, as it increases our understanding of the communicative sequelae of traumatic brain injury, will provide a more comprehensive framework from which to evaluate and treat these individuals. The NIDCD encourages both basic and clinical investigations in the speech, language, and voice components of disorders of communication following traumatic brain injury. Examples of issues to be addressed in applications submitted in response to this program announcement include, but are not limited to, the following: o Development of test materials that are appropriate and sensitive to the communication difficulties specific to the TBI population. o Development of standardized assessment profiles for the speech disorders following TBI based on perceptual, acoustical, and physiological data, which taken together will provide a firm basis for understanding the impaired functions of respiration, phonation, and articulation. o Objective assessment of the progression of disorders of the respiratory, laryngeal, velopharyngeal, and articulatory systems, and examination of the characteristics of speech and voice disorders resulting from TBI. o Examination and comparison of the loss and redevelopment of speech control following traumatic brain injury in the pediatric and adult populations with particular reference to neural plasticity. o Examination of the role of critical age periods for speech and language performance in relation to recovery from injury, and the cellular and molecular mechanisms involved. o Multidisciplinary outcome studies that combine imaging with detailed analysis of processes underlying language function and reorganization. o Characterization of the long-term sequelae of traumatic brain injury as manifest in speech, swallowing, voice and language disabilities during recovery stages. o Development of improved therapeutic tools for rehabilitation of communication skills in individuals with TBI. o Outcome studies to evaluate the effectiveness of intervention and to track recovery of communication skills over the long term. INCLUSION OF WOMEN AND MINORITIES RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion in inappropriate with respect to the health of the subjects or the purpose of the research. This new policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43) and supersedes and strengthens the previous policies (Concerning the Inclusion of Women in Study Populations, and Concerning the Inclusion of Minorities in Study Populations), which have been in effect since 1990. The new policy contains some provisions that are substantially different from the 1990 policies. All investigators proposing research involving human subjects should read the "NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical Research," which have been published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and reprinted in the NIH Guide for Grants and Contracts, Volume 23, Number 11, March 18, 1994. Investigators also may obtain copies of the policy from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. APPLICATION PROCEDURES Applications are to be submitted on the grant application form PHS 398 (rev. 9/91) and will be accepted at the standard application deadlines as indicated in the application kit. These kits are available from most institutional offices of sponsored research; the Office of Grants Information, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 710-0267; and from the NIDCD Program Administrator listed under INQUIRIES. The title and number of the program announcement must be typed in Section 2a on the face page of the application. Applications for the FIRST Award (R29) must include at least three sealed letters of reference attached to the face page of the original application. FIRST Award (R29) applications submitted without the required number of reference letters will be considered incomplete and will be returned without review. The completed original application and five legible copies must be sent or delivered to: Division of Research Grants National Institutes of Health 6701 Rockledge Drive, MSC 7710 Bethesda, MD 20892-7710 Bethesda, MD 20817 (express mail) REVIEW CONSIDERATIONS Applications will be assigned on the basis of established PHS referral guidelines. Applications will be reviewed for scientific and technical merit by an appropriate Initial Review Group within the Division of Research Grants, NIH, in accordance with the standard NIH peer review procedures. Following scientific-technical review, the applications will receive a second-level review by the appropriate national advisory council. Applications that are complete and responsive to the program announcement will be evaluated for scientific and technical merit by an appropriate peer review group convened in accordance with the standard NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of applications under review, will be discussed, assigned a priority score, and receive a second level review by the appropriate national advisory council or board. AWARD CRITERIA Applications will compete for available funds with all other applications assigned to that Institute. The following will be considered in making funding decisions: o Quality of the proposed project as determined by peer review o Availability of funds o Program priorities among research areas of the program announcement INQUIRIES Written and telephone inquiries concerning this PA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Beth Ansel, Ph.D. Division of Human Communication National Institute on Deafness and Other Communication Disorders Executive Plaza South, Room 400-C 6120 Executive Boulevard MSC 7180 Bethesda, MD 20892-7180 Telephone: (301) 402-3461 FAX: (301) 402-6251 Email: AnselB%NIDCD-EPS%NIH@fedtcp.ninds.nih.gov Direct inquiries regarding fiscal matters to: Sharon Hunt Grants Management Officer National Institute on Deafness and Other Communication Disorders Executive Plaza South, Room 400-B 6120 Executive Boulevard MSC 7180 Bethesda, MD 20892-7180 Telephone: (301) 402-0909 Email: HuntS%NIDCD-EPS%NIH@fedtcp.ninds.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.173. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people. .
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