NIH GUIDE, Volume 21, Number 24, July 3, 1992

PA NUMBER:  PA-92-89

P.T. 34


  Disease Model 

  Animal Breed. & Facil., Scientific 

  Computer Modeling 

National Center for Research Resources


The Biological Models and Materials Research Program (BMMRP) of the

National Center for Research Resources (NCRR) is reissuing this program

announcement to encourage the submission of applications for the

development of high connectivity nonmammalian models for biomedical



Applications may be submitted by foreign and domestic, for-profit and

non-profit organizations, public and private, such as universities,

colleges, hospitals, laboratories, units of State and local

governments, and eligible agencies of the Federal Government.

Applications from minority individuals and women are encouraged.

Foreign institutions are not eligible for the First Independent

Research Support and Transition (FIRST) Award.


The support mechanisms for this program will be the individual

investigator-initiated research project grant (R01) and the FIRST Award

(R29).  Under these mechanisms the applicant will plan, direct, and

carry out the research program.  The proposed project period during

which the research will be conducted should adequately reflect the time

required to accomplish the stated goals and be consistent with the

policy for grant support.


The objective of this program announcement is to stimulate research on

the development of high connectivity nonmammalian models for biomedical

research as follows:

o  Organismic, including all poikilotherms, but not homeotherms, lower

organisms (such as fishes, invertebrates, and microorganisms).

o  In vitro systems such as established cell lines from any species or

cell or tissue culture from poikilothermic sources.

o  Mathematical or computer models, in particular if closely coupled to

biological experimentation.  There are opportunities for mathematical

modeling in many areas of biomedical research and at all levels of

biological organization.

A high connectivity model is one in which:

o  The body of knowledge about the system is large and has resulted in

extensive cross information, or connection, with other systems.

Examples of organisms that have many characterized properties or

functions include, but are not limited to, Drosophila melanogaster,

Caenorhabditis elegans, Escherichia coli, Aplysia sp., Xenopus sp.,

Arabidopsis sp., and sea urchins.

o  A function or property is broadly retained across many taxa.

Examples include cytoskeletal structure, cell adhesion, cytochrome c,

hormones, hormone receptors, and genetic regulation.

o  The research involves broad intertaxonomic projects.


Applications are to be submitted on the grant application form PHS 398

(rev. 9/91) and will be accepted at the standard application deadlines

as indicated in the application kit, i.e., June 1, October 1, and

February 1.

Application kits are available at most institutional business offices

and may be obtained from the Office of Grants Inquiries, Division of

Research Grants, National Institutes of Health, Westwood Building, Room

449, Bethesda, MD  20892, telephone (301) 496-7441.

To identify the application as in response to this announcement, check

"yes" in item 2a on the face page of the application and enter the PA

number and the title, "High Connectivity Nonmammalian Models".

The completed original application and five legible copies must be sent

or delivered to:

Division of Research Grants

National Institutes of Health

Westwood Building, Room 240

Bethesda, MD  20892**


Applications will be received by the National Institutes of Health

(NIH), Division of Research Grants (DRG), and referred to an

appropriate Initial Review Group (IRG) for scientific and technical

review.  Institute assignment decisions will be governed by customary

programmatic considerations as specified in the NIH Referral

Guidelines.  Some applications may receive secondary assignments.

Following the initial scientific review, the applications will be

evaluated by the National Advisory Research Resources Council or

another appropriate institute council/board.


Applications will compete for available funds with all other approved

applications assigned to that ICD.  The following will be considered

when making funding decisions:

o  Quality of the proposed project as determined by peer review

o  Availability of funds

o  Program balance among research areas of the announcement


Written and telephone inquiries are encouraged.  The opportunity to

clarify any issues or questions from potential applicants is welcome.

Direct inquiries regarding programmatic issues to:

Dr. Louise E. Ramm, Ph.D.

Director, Biological Models and Materials Research Program

National Center for Research Resources

Westwood Building, Room 8A07

5333 Westbard Avenue

Bethesda, MD  20892

Telephone:  (301) 402-0630

Direct inquiries regarding fiscal matters to:

Ms. Mary V. Niemiec

Supervisory Grants Management Specialist

Office of Grants and Contracts Management

National Center for Research Resources

Westwood Building, Room 849

Bethesda, MD  20892

Telephone:  (301) 496-9840


This program is described in the Catalog of Federal Domestic Assistance

No. 93.198.  Awards are made under authorization of the Public Health

Service Act, Title III, Part A (Public Law 78-410, as amended by Public

Law 99-158, 42 USC 241) and administered under PHS grants policies and

Federal Regulations 42 CFR 52 and 45 CFR Part 74.  This program is not

subject to the intergovernmental review requirements of Executive Order

12372 or Health Systems Agency review.


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