DEVELOPMENT OF HIGH CONNECTIVITY NONMAMMALIAN MODELS NIH GUIDE, Volume 21, Number 24, July 3, 1992 PA NUMBER: PA-92-89 P.T. 34 Keywords: Disease Model Animal Breed. & Facil., Scientific Computer Modeling National Center for Research Resources PURPOSE The Biological Models and Materials Research Program (BMMRP) of the National Center for Research Resources (NCRR) is reissuing this program announcement to encourage the submission of applications for the development of high connectivity nonmammalian models for biomedical research. ELIGIBILITY REQUIREMENTS Applications may be submitted by foreign and domestic, for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal Government. Applications from minority individuals and women are encouraged. Foreign institutions are not eligible for the First Independent Research Support and Transition (FIRST) Award. MECHANISMS OF SUPPORT The support mechanisms for this program will be the individual investigator-initiated research project grant (R01) and the FIRST Award (R29). Under these mechanisms the applicant will plan, direct, and carry out the research program. The proposed project period during which the research will be conducted should adequately reflect the time required to accomplish the stated goals and be consistent with the policy for grant support. RESEARCH OBJECTIVES The objective of this program announcement is to stimulate research on the development of high connectivity nonmammalian models for biomedical research as follows: o Organismic, including all poikilotherms, but not homeotherms, lower organisms (such as fishes, invertebrates, and microorganisms). o In vitro systems such as established cell lines from any species or cell or tissue culture from poikilothermic sources. o Mathematical or computer models, in particular if closely coupled to biological experimentation. There are opportunities for mathematical modeling in many areas of biomedical research and at all levels of biological organization. A high connectivity model is one in which: o The body of knowledge about the system is large and has resulted in extensive cross information, or connection, with other systems. Examples of organisms that have many characterized properties or functions include, but are not limited to, Drosophila melanogaster, Caenorhabditis elegans, Escherichia coli, Aplysia sp., Xenopus sp., Arabidopsis sp., and sea urchins. o A function or property is broadly retained across many taxa. Examples include cytoskeletal structure, cell adhesion, cytochrome c, hormones, hormone receptors, and genetic regulation. o The research involves broad intertaxonomic projects. APPLICATION PROCEDURES Applications are to be submitted on the grant application form PHS 398 (rev. 9/91) and will be accepted at the standard application deadlines as indicated in the application kit, i.e., June 1, October 1, and February 1. Application kits are available at most institutional business offices and may be obtained from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 496-7441. To identify the application as in response to this announcement, check "yes" in item 2a on the face page of the application and enter the PA number and the title, "High Connectivity Nonmammalian Models". The completed original application and five legible copies must be sent or delivered to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** REVIEW PROCEDURES Applications will be received by the National Institutes of Health (NIH), Division of Research Grants (DRG), and referred to an appropriate Initial Review Group (IRG) for scientific and technical review. Institute assignment decisions will be governed by customary programmatic considerations as specified in the NIH Referral Guidelines. Some applications may receive secondary assignments. Following the initial scientific review, the applications will be evaluated by the National Advisory Research Resources Council or another appropriate institute council/board. AWARD CRITERIA Applications will compete for available funds with all other approved applications assigned to that ICD. The following will be considered when making funding decisions: o Quality of the proposed project as determined by peer review o Availability of funds o Program balance among research areas of the announcement INQUIRIES Written and telephone inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Dr. Louise E. Ramm, Ph.D. Director, Biological Models and Materials Research Program National Center for Research Resources Westwood Building, Room 8A07 5333 Westbard Avenue Bethesda, MD 20892 Telephone: (301) 402-0630 Direct inquiries regarding fiscal matters to: Ms. Mary V. Niemiec Supervisory Grants Management Specialist Office of Grants and Contracts Management National Center for Research Resources Westwood Building, Room 849 Bethesda, MD 20892 Telephone: (301) 496-9840 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.198. Awards are made under authorization of the Public Health Service Act, Title III, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. .
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