This Program Announcement expires on July 31, 2004, unless reissued.
THE MANAGEMENT OF CHRONIC PAIN
Release Date: July 2, 2001
PA NUMBER: PA-01-115
National Institute of Nursing Research (NINR)
National Institute on Aging (NIA)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Center for Complementary and Alternative Medicine (NCCAM)
National Cancer Institute (NCI)
National Institute of Child Health and Human Development (NICHD)
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute on Drug Abuse (NIDA)
National Institute of Neurological Disorders and Stroke (NINDS)
THIS PA USES THE "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. IT INCLUDES
DETAILED MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE USED
WHEN PREPARING APPLICATIONS IN RESPONSE TO THIS PA.
PURPOSE
The National Institute of Nursing Research and co-sponsoring Institutes and
Centers encourage research proposals in the management of chronic pain across
the lifespan. Pain is a subjective experience influenced by gender, age,
race/ethnicity and psychosocial factors. The management of pain is influenced
by patient, health care provider and system factors. Research is needed to
determine the most effective interventions to remove barriers to effective
treatment, to determine the most effective pharmacological and non-
pharmacological therapies including complementary and alternative therapies,
to identify assessment tools for patients unable to verbalize their pain, and
to identify effective pain management strategies for individuals with
disabilities and underserved populations.
HEALTHY PEOPLE 2010
The Public Health Service (PHS) is committed to achieving the health promotion
and disease prevention objectives of "Healthy People 2010," a PHS led national
activity for setting priority areas. This Program Announcement (PA), The
Management of Chronic Pain, is related to one or more of the priority areas.
Potential applicants may obtain a copy of "Healthy People 2010" at
http://www.health.gov/healthypeople/.
ELIGIBILITY REQUIREMENTS
Applications may be submitted by domestic and foreign, for-profit and non-
profit organizations, public and private, such as universities, colleges,
hospitals, laboratories, units of State and local governments, and eligible
agencies of the Federal government. Racial/ethnic minority individuals,
women, and persons with disabilities are encouraged to apply as principal
investigators.
MECHANISM OF SUPPORT
This PA will use the National Institutes of Health (NIH) Research Project
Grant (R01) award mechanism. Responsibility for the planning, direction, and
execution of the proposed project will be solely that of the applicant. The
total project period for an application submitted in response to this PA may
not exceed 5 years.
Specific application instructions have been modified to reflect "MODULAR
GRANT" and "JUST-IN-TIME" streamlining efforts being examined by the NIH.
Complete and detailed instructions and information on Modular Grant
applications can be found at
http://grants.nih.gov/grants/funding/modular/modular.htm
RESEARCH OBJECTIVES
There are more than 50 million Americans who experience chronic pain and more
than half of dying patients experience moderate to severe pain during the last
days of their life. Pain is a frequent cause for clinical visits with
approximately 45% of the population seeking medical help for pain at some
point in their lives. Pain is found across the lifespan and it has been
estimated that four out of every ten people with moderate or severe pain do
not get adequate relief.
Pain is personal and subjective, is affected by mood and psychosocial factors,
and demonstrates tremendous individual variation. Depression commonly
complicates pain and adds to the disability and impairment found in disorders
with chronic pain. Pain in combination with depression is a risk factor for
suicide. Pain interferes with quality of life, sleep and productivity, and
pain increases utilization of health care resources. However, many health
care providers do not have the background to effectively treat pain.
Pain is frequently undertreated by healthcare providers. For example, a
survey of several hundred ambulatory AIDS patients found that fewer than 8% of
patients reporting "severe" pain were prescribed a strong opioid such as
morphine, despite published guidelines. Adjuvant analgesic drugs (e.g.,
antidepressants) were also prescribed to only a small fraction of these
patients. Opioid analgesics are the accepted treatment for acute pain, cancer
pain and pain at the end of life, and recently have been recommended for
chronic, nonmalignant pain. Patients can be treated with this therapy without
developing tolerance, addiction or toxicity. Nevertheless, health care
providers continue to fear these adverse outcomes, and believe that opioid use
may result in a downhill spiral of further disability, depression and pain, in
spite of contrary evidence. A further barrier to chronic opioid therapy is
the lack of a good objective measure to determine whether a person requesting
increased opioid dosage is abusing opioids or is receiving insufficient
benefit from therapy. This second scenario is so common in certain conditions
(e.g., cancer, sickle cell disease) that the term pseudo addiction, has been
used to describe the patient who is demonstrating drug-seeking behavior
because his or her pain is undertreated.
In addition to health care provider barriers, there are patient and family
barriers to effective pain relief. Patients may underuse effective
pharmacological treatments because of a stoic or fatalistic attitude, and/or a
belief that complaining of pain makes one a bad patient. Patients with
cancer may believe that cancer pain cannot be alleviated, they may fear that
pain indicates disease progression and/or they may fear that current usage
will lead to future ineffectiveness. Patients who are treated with opioids
may have additional fears of dependence, addiction and tolerance, and fear of
injections. Thus, underusage may also be due to the stigma of using opioids.
Research is needed to determine the relationship between patient-related
barriers and pain management and to determine whether the patient barriers are
a cause or result of inadequate treatment.
Pain and pain management in infants is another area of research need.
Premature infants often undergo painful medical and surgical procedures and
may be in ongoing pain as a result. Until recently it was believed that
infants are insensitive to pain because of their immature nervous systems.
Recent research demonstrates that infants do feel pain and a recent study on
an animal model demonstrated that the pain experienced as a neonate resulted
in greater sensitivity to pain as an adult. Thus, painful procedures in
infancy may lead to permanent changes in the pain threshold. Effective pain
interventions are needed for premature infants who are now surviving due to
medical and technical advances.
Individuals with certain demographic characteristics or medical conditions are
likely to experience less effective pain management and report higher pain
levels than others. Older patients are often undertreated, especially the
cognitively impaired. Women may experience further undertreatment as they are
over represented in certain conditions associated with pain such as
fibromyalgia and temporomandibular joint disorders. In addition, individuals
with less education or lower incomes, minority patients, patients with a
history of injection drug use, and patients with AIDS are at risk for
receiving suboptimal pain treatment. The specific barriers to the
undertreatment and underuseage of pain medication and non-pharmacological
regimens need to be identified in these underserved populations.
Similarly, chronic pain is frequently undertreated in those who are unable to
verbalize their pain (e.g., premature infants, cognitively impaired
individuals). Assessment of chronic pain in nonverbal populations is
difficult. Sympathetic arousal is frequently found in acute pain, but is not
commonly found in patients with chronic pain and therefore a patient may not
look as if s/he is in pain. The cues suggesting pain in nonverbal patients
can be identified by those who are familiar with the patient and who can
detect changes in behavior. However, in any health care facility and
particularly the long-term care facility, the staff turnover and different
patient assignments are barriers to the assessment of pain in nonverbal
patients. Some cognitively impaired elders can report pain reliably in
response to simple questions. However, pain needs to be assessed in order to
be treated. The Department of Veterans Affairs and other health care
institutions have institutionalized the assessment of pain as a fifth vital
sign, similar to other vital signs like blood pressure, pulse, temperature and
respiratory rate. Other innovative systematic approaches to pain management
are needed. Educational training is not sufficient for instituting changes in
pain management, further research on other institutional changes is needed to
support pain management interventions in the practice setting.
Non-pharmacological treatments have been found to be effective in managing
chronic pain either alone or in combination with pharmacological therapy.
These treatments include relaxation training, cognitive behavioral
interventions, family support, biofeedback, and improving self-efficacy.
Further research is needed to refine the most effective treatment strategies
for specific conditions and to determine the most effective treatment
strategies for underserved populations. This research should include
investigation of innovative complementary and alternative therapies for the
effective treatment of chronic pain such as acupuncture, spinal manipulation
and botanical products. A recent report concluded that there is little
research on the management of cancer pain. The report recommended that
further research is needed to determine the best combinations of
pharmacological and non-pharmacological regimens in long-term cancer patients
and in children with cancer pain. In addition, further research is needed to
determine the impact of ethnicity, race, gender, age, psychosocial context and
culture on cancer pain.
Listed below are examples of studies that would be responsive to this program
announcement. However, these are only illustrative examples and applicants
are encouraged to propose other topics consistent with the goals of this
program.
o Test interventions to remove the barriers to the effective treatment of
pain by health care providers for all patients including those who are
underserved,
o Test interventions to remove the barriers to the usage of pharmacological
therapy by patients,
o Determine factors associated with the under-reporting of chronic pain
and/or reporting that a treatment is effective when pain is not relieved,
o Develop and test measurement tools to assess chronic pain in patients who
are unable to verbalize their pain (e.g., infants, patients with dementia),
o Further explore the relationship between painful procedures and future pain
sensitivity in premature infants,
o Identify innovative biobehavioral interventions to control and alleviate
chronic pain and the associated psychological distress in clinical and home
settings,
o Identify and test complementary and alternative therapies either alone or
in combination with conventional therapies for the control and alleviation of
chronic pain,
o Test innovative methods for translating scientific advances in pain
management into practice settings,
o Identify which of the patient barriers are a cause or a result of
psychological distress,
o Develop a clinically effective monitoring system for opioid adherence and
objective measures of tolerance and addiction,
o Identify the patient and/or health care provider barriers associated with
the underusage or undertreatment of pain specific for different cultural and
ethnic/minority populations,
o Test non-pharmacological interventions separately and in combination with
pharmacological interventions to determine the most effective chronic pain
management regimen,
o Determine whether sensitivity or reactivity to pain is affected by dementia
in the elderly,
o Investigate the consequences of pharmacological pain management on
cognition and functional abilities in the elderly, and particularly in persons
with dementia,
o Use psychophysical techniques to investigate pain threshold changes
throughout the lifespan in patients experiencing chronic pain,
o Study nociceptive pathways in older people with and without chronic pain
using neuroimaging methods,
o Study assessment and treatment of chronic pain in drug abusing populations
both in and out of drug abuse treatment and study the effects of under-,
over-, and appropriate treatment of chronic pain on the development and
relapse of drug abuse,
o Study interactions among drugs of abuse, medications used to treat drug
abuse and its co-morbid conditions and medications used to treat drug abuse,
and
o Assess the medical/health consequences of abused/over-used pain
medications.
INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of the NIH that women and members of minority groups and
their sub-populations must be included in all NIH-supported biomedical and
behavioral research projects involving human subjects, unless a clear and
compelling rationale and justification are provided indicating that inclusion
is inappropriate with respect to the health of the subjects or the purpose of
the research. This policy results from the NIH Revitalization Act of 1993
(Section 492B of Public Law 103-43).
All investigators proposing research involving human subjects should read the
UPDATED "NIH Guidelines for Inclusion of Women and Minorities as Subjects in
Clinical Research," published in the NIH Guide for Grants and Contracts on
August 2, 2000
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html),
a complete copy of the updated Guidelines are available at
http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm: The
revisions relate to NIH defined Phase III clinical trials and require: a) all
applications or proposals and/or protocols to provide a description of plans
to conduct analyses, as appropriate, to address differences by sex/gender
and/or racial/ethnic groups, including subgroups if applicable, and b) all
investigators to report accrual, and to conduct and report analyses, as
appropriate, by sex/gender and/or racial/ethnic group differences.
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by the
NIH, unless there are scientific and ethical reasons not to include them.
This policy applies to all initial (Type 1) applications submitted for receipt
dates after October 1, 1998.
All investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines on the Inclusion of Children as Participants in
Research Involving Human Subjects" that was published in the NIH Guide for
Grants and Contracts, March 6, 1998, and is available at the following URL
address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html
Investigators also may obtain copies of these policies from the program staff
listed under INQUIRIES. Program staff may also provide additional relevant
information concerning the policy.
REQUIRED EDUCATION IN THE PROTECTION OF HUMAN RESEARCH PARTICIPANTS
All investigators proposing research involving human subjects should read the
policy that was published in the NIH Guide for Grants an Contracts, June 5,
2000 (Revised August 25, 2000), available at:
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.
URLS IN NIH GRANT APPLICATIONS OR APPENDICES
All applications and proposals for NIH funding must be self-contained within
specified page limitations. Unless otherwise specified in an NIH
solicitation, Internet addresses (URLs) should not be used to provide
information necessary to the review because reviewers are under no obligation
to view the Internet sites. Reviewers are cautioned that their anonymity may
be compromised when they directly access an Internet site.
PUBLIC ACCESS TO RESEARCH DATA THROUGH THE FREEDOM OF INFORMATION ACT
The Office of Management and Budget (OMB) Circular A-110 has been revised to
provide public access to research data through the Freedom of Information Act
(FOIA) under some circumstances. Data that are (1) first produced in a
project that is supported in whole or in part with Federal funds and (2) cited
publicly and officially by a Federal agency in support of an action that has
the force and effect of law (i.e., a regulation) may be accessed through FOIA.
It is important for applicants to understand the basic scope of this
amendment. NIH has provided guidance at:
http://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm
Applicants may wish to place data collected under this RFA in a public
archive, which can provide protections for the data and manage the
distribution for an indefinite period of time. If so, the application should
include a description of the archiving plan in the study design and include
information about this in the budget justification section of the application.
In addition, applicants should think about how to structure informed consent
statements and other human subjects procedures given the potential for wider
use of data collected under this award.
APPLICATION PROCEDURES
Applications are to be submitted on the grant application form PHS 398 (rev.
4/98) and will be accepted at the standard application deadlines as indicated
in the application kit. Application kits are available at most institutional
offices of sponsored research and may be obtained from the Division of
Extramural Outreach and Information Resources, National Institutes of Health,
6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267, email: GrantsInfo@nih.gov.
Applicants planning to submit an investigator-initiated new (type 1),
competing continuation (type 2), competing supplement, or any amended/revised
version of the preceding grant application types requesting $500,000 or more
in direct costs for any year are advised that he or she must contact the
Institute or Center (IC) program staff before submitting the application, i.e,
as plans for the study are being developed. Furthermore, the application must
obtain agreement from the IC staff that the IC will accept the application for
consideration for award. Finally, the applicant must identify, in a cover
letter sent with the application, the staff member and Institute or Center who
agreed to accept assignment of the application.
This policy requires an applicant to obtain agreement for acceptance of both
any such application and any such subsequent amendment. Refer to the NIH
Guide for Grants and Contracts, March 20, 1998 at
http://grants.nih.gov/grants/guide/notice-files/not98-030.html
The modular grant concept establishes specific modules in which direct costs
may be requested as well as a maximum level for requested budgets. Only
limited budgetary information is required under this approach. The
just-in-time concept allows applicants to submit certain information only when
there is a possibility for an award. It is anticipated that these changes will
reduce the administrative burden for the applicants, reviewers and Institute
staff. The research grant application form PHS 398 (rev. 4/98) is to be used
in applying for these grants, with the modifications noted below.
SPECIFIC INSTRUCTIONS FOR MODULAR GRANT APPLICATIONS
BUDGET INSTRUCTIONS
Modular Grant applications will request direct costs in $25,000 modules, up to
a total direct cost request of $250,000 per year. (Applications that request
more than $250,000 direct costs in any year must follow the traditional PHS
398 application instructions.) The total direct costs must be requested in
accordance with the program guidelines and the modifications made to the
standard PHS 398 application instructions described below:
PHS 398
o FACE PAGE: Items 7a and 7b should be completed, indicating Direct Costs (in
$25,000 increments up to a maximum of $250,000) and Total Costs [Modular Total
Direct plus Facilities and Administrative (F&A) costs] for the initial budget
period Items 8a and 8b should be completed indicating the Direct and Total
Costs for the entire proposed period of support.
o DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD - Do not complete Form Page 4
of the PHS 398. It is not required and will not be accepted with the
application.
o BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT - Do not complete the
categorical budget table on Form Page 5 of the PHS 398. It is not required and
will not be accepted with the application.
o NARRATIVE BUDGET JUSTIFICATION - Prepare a Modular Grant Budget Narrative
page. (See http://grants.nih.gov/grants/funding/modular/modular.htm for sample
pages.) At the top of the page, enter the total direct costs requested for
each year. This is not a Form page.
o Under Personnel, list all project personnel, including their names, percent
of effort, and roles on the project. No individual salary information should
be provided. However, the applicant should use the NIH appropriation language
salary cap and the NIH policy for graduate student compensation in developing
the budget request.
For Consortium/Contractual costs, provide an estimate of total costs (direct
plus facilities and administrative) for each year, each rounded to the nearest
$1,000. List the individuals/organizations with whom consortium or contractual
arrangements have been made, the percent effort of all personnel, and the role
on the project. Indicate whether the collaborating institution is foreign or
domestic. The total cost for a consortium/contractual arrangement is included
in the overall requested modular direct cost amount. Include the Letter of
Intent to establish a consortium.
Provide an additional narrative budget justification for any variation in the
number of modules requested.
o BIOGRAPHICAL SKETCH - The Biographical Sketch provides information used by
reviewers in the assessment of each individual"s qualifications for a specific
role in the proposed project, as well as to evaluate the overall
qualifications of the research team. A biographical sketch is required for all
key personnel, following the instructions below. No more than three pages may
be used for each person. A sample biographical sketch may be viewed at:
http://grants.nih.gov/grants/funding/modular/modular.htm
- Complete the educational block at the top of the form page,
- List position(s) and any honors,
- Provide information, including overall goals and responsibilities, on
research projects ongoing or completed during the last three years.
- List selected peer-reviewed publications, with full citations,
o CHECKLIST - This page should be completed and submitted with the
application. If the F&A rate agreement has been established, indicate the type
of agreement and the date. All appropriate exclusions must be applied in the
calculation of the F&A costs for the initial budget period and all future
budget years.
o The applicant should provide the name and phone number of the individual to
contact concerning fiscal and administrative issues if additional information
is necessary following the initial review.
The title and number of the program announcement must be typed on line 2 of
the face page of the application form and the YES box must be marked.
Submit a signed, typewritten original of the application, including the
Checklist, and five signed photocopies in one package to:
CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710
BETHESDA, MD 20892-7710
BETHESDA, MD 20817 (for express/courier service)
REVIEW CONSIDERATIONS
Applications will be assigned on the basis of established PHS referral
guidelines. Applications will be evaluated for scientific and technical merit
by an appropriate scientific review group convened in accordance with the
standard NIH peer review procedures. As part of the initial merit review, all
applications will receive a written critique and undergo a process in which
only those applications deemed to have the highest scientific merit, generally
the top half of applications under review, will be discussed, assigned a
priority score, and receive a second level review by the appropriate national
advisory council or board.
Review Criteria
The goals of NIH-supported research are to advance our understanding of
biological systems, improve the control of disease, and enhance health. In
the written comments reviewers will be asked to discuss the following aspects
of the application in order to judge the likelihood that the proposed research
will have a substantial impact on the pursuit of these goals. Each of these
criteria will be addressed and considered in assigning the overall score,
weighting them as appropriate for each application. Note that the application
does not need to be strong in all categories to be judged likely to have major
scientific impact and thus deserve a high priority score. For example, an
investigator may propose to carry out important work that by its nature is not
innovative but is essential to move a field forward.
(1) Significance: Does this study address an important problem? If the aims
of the application are achieved, how will scientific knowledge be advanced?
What will be the effect of these studies on the concepts or methods that drive
this field?
(2) Approach: Are the conceptual framework, design, methods, and analyses
adequately developed, well-integrated, and appropriate to the aims of the
project? Does the applicant acknowledge potential problem areas and consider
alternative tactics?
(3) Innovation: Does the project employ novel concepts, approaches or method?
Are the aims original and innovative? Does the project challenge existing
paradigms or develop new methodologies or technologies?
(4) Investigator: Is the investigator appropriately trained and well suited
to carry out this work? Is the work proposed appropriate to the experience
level of the principal investigator and other researchers (if any)?
(5) Environment: Does the scientific environment in which the work will be
done contribute to the probability of success? Do the proposed experiments
take advantage of unique features of the scientific environment or employ
useful collaborative arrangements? Is there evidence of institutional
support?
In addition to the above criteria, in accordance with NIH policy, all
applications will also be reviewed with respect to the following:
o The adequacy of plans to include both genders, minorities and their
subgroups, and children as appropriate for the scientific goals of the
research. Plans for the recruitment and retention of subjects will also be
evaluated.
o The reasonableness of the proposed budget and duration in relation to the
proposed research
o The adequacy of the proposed protection for humans, animals or the
environment, to the extent they may be adversely affected by the project
proposed in the application.
AWARD CRITERIA
Applications will compete for available funds with all other recommended
applications. The following will be considered in making funding decisions:
Quality of the proposed project as determined by peer review, availability of
funds, and program priority.
INQUIRIES
Inquiries are encouraged. The opportunity to clarify any issues or questions
from potential applicants is welcome.
Direct inquiries regarding programmatic issues to:
Dr. Karin Helmers
Office of Extramural Programs
National Institute of Nursing Research
Building 45, Room Number 3AN12, MSC 6300
Bethesda, MD 20892-6300
Telephone: (301) 594-2177
FAX: (301) 480-8260
Email: Karin_helmers@nih.gov
Dr. Elisabeth Koss
Neuroscience and Neuropsychology of Aging Program
National Institute on Aging
7201 Wisconsin Avenue, Suite 3C307 MSC 9205
Bethesda, MD 20892-9205
Telephone: (301) 496-9350
FAX: (301) 496-1494
Email: kosse@nia.nih.gov
Dr. Deborah N. Ader
Director, Behavioral and Prevention Research Program
National Institute of Arthritis and Musculoskeletal and Skin Diseases
45 Center Drive, Building 45, Room 5A19H
Bethesda, MD 20892-6500
Telephone: (301) 594-5032
FAX: (301) 480-4543
Email: adere@mail.nih.gov
Dr. Nancy Pearson
Program Officer
Neuroscience, Mental Health, NRSA Training Programs
National Center for Complementary and Alternative Medicine
6707 Democracy Boulevard, Room 106, MSC 5475
Bethesda, MD 20892-5475
Telephone: (301) 594-0519
FAX: (301) 480-3621
Email: pearsonn@mail.nih.gov
Dr. Christine Goertz
Program Officer
Musculoskeletal Disease, Skin Disease, Addiction, Health Services Research
National Center for Complementary and Alternative Medicine
6707 Democracy, Boulevard, Room 106, MSC 5475
Bethesda, MD 20892-5475
Telephone: (301) 402-1030
FAX: (301) 480-3621
Email: Goertzc@mail.nih.gov
Dr. Claudette Varricchio
Program Director
Division of Cancer Prevention
National Cancer Institute
6130 Executive Blvd. EPN 300
Bethesda, MD, 20892
Telephone: (301) 496-8541
FAX: (301) 496-8667
Email: varriccc@mail.nih.gov
Dr. Beth M. Ansel
National Center for Medical Rehabilitation Research
National Institute of Child Health and Human Development
6100 Executive Boulevard, Room 2A03, MSC 7510
Bethesda, MD 20892-7510
Telepohone: (301) 402-2242
FAX: (301) 402-0832
E-mail: Beth_Ansel@nih.gov
Dr. Kenneth A. Gruber
Chief, Chronic Diseases Branch
Division of Extramural Research
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-18C
Bethesda, MD 20892-6402
Telephone: (301) 594-4836
FAX: (301) 480-8318
Email: Kenneth.Gruber@nih.gov
Dr. Jag H. Khalsa
Health Scientist Administrator
Center on AIDS & Other Medical Consequences of Drug Abuse (CAMCODA)
National Institute on Drug Abuse
6001 Executive Boulevard, Rm 5198, MSC 9593
Bethesda, MD 20892-9593
Telephone: (301) 443-1801 (443-2159 direct)
FAX: (301) 443-4100
e-mail: jk98p@nih.gov
Dr. Cheryl Kitt
Program Director
Systems and Cognitive Neuroscience
National Institute of Neurological Disorders and Stroke
6001 Executive Blvd., Rm. 2116
Rockville, MD 20892
Telephone: 301-496-9964
FAX: 301-402-2060
Email: kittc@ninds.nih.gov
Direct inquiries regarding fiscal matters to:
Ms. Sally York
Office of Grants and Contract Management
National Institute of Nursing Research
Building 45, Room Number 3AN12, MSC 6300
Bethesda, MD 20892-6300
Telephone: (301) 594-2154
FAX: (301) 480-8260
Email: Sally_york@nih.gov
Ms. Linda Whipp
Grants Management Officer
Grants and Contracts Management Office
National Institute on Aging
7201 Wisconsin Avenue, Suite 2N212, MSC 9205
Bethesda, MD 20892-9205
Telephone: (301) 496-1472
FAX: (301) 402-3672
Email: lw17m@nih.gov
Melinda B. Nelson
Chief Grants Management Officer
National Institute of Arthritis and Musculoskeletal and Skin Diseases
45 Center Drive, Room 5AS49
Bethesda, Maryland 20892
Telephone: (301) 435-5278
FAX: (301) 480-4543
Email: nelsonm@mail.nih.gov
Ms. Victoria Carper
National Center for Complementary and Alternative Medicine (NCCAM)
National Institutes of Health
6707 Democracy Blvd. Suite 106
Bethesda, MD 20892-5475
(FedEx, UPS or other courier use zip code 20817)
Telephone: (301) 594-9102
FAX: (301) 480-3621
Email: carperv@mail.nih.gov
Ms. Eileen Natoli
Grants Administration Branch
National Cancer Institute
6120 Executive Boulevard, Room 243, MSC 7150
Rockville, MD 20892-7150
Telephone: (301) 496-8791
FAX: (301) 402-0275
Email: natolie@gab.nci.nih.gov
Mr. Christopher Myers
Grants Management Branch
National Institute of Child Health and Human Development
6100 Executive Boulevard, Room 8A17H, MSC 7510
Bethesda, MD m20892-7510
Telephone: (301)435-6996
FAX: (301) 402-0915
E-mail: cm143g@nih.gov
Mr. Martin Rubinstein
Office of Grants Management
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-44A
Bethesda, MD 20892-6402
Telephone: (301) 594-4800
FAX: (301) 480-8301
Email: Martin.Rubinstein@nih.gov
Mr. Gary Fleming
Grants Management Branch
National Institute on Drug Abuse
6001 Executive Boulevard, Room 3131, MSC 9541
Bethesda, MD 20892-9541
Telephone: (301) 443-6710
FAX : (301) 594-6847
E-mail: gf6s@nih.gov
Ms. Sheila Simmons
Grants Management Branch
National Institute of Neurological Disorders and Stroke
6001 Executive Boulevard
Rockville, MD 20892
Telephone: (301) 496-8084
FAX : (301) 402-0219
E-mail: ss443y@nih.gov
AUTHORITY AND REGULATIONS
This program is described in the Catalog of Federal Domestic Assistance No.
93.361 (NINR), 93.866 (NIA), 93.846 (NIAMS), 93.213 (NCCAM), 93.393 (NCI),
93.929 (NICHD), 93.158 (NIDCR), 93.279 (NIDA), and 93.853 (NINDS). Awards are
made under authorization of sections 301 and 405 of the Public Health Service
Act as amended (42 USC 241 and 284) and administered under NIH grants policies
and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is
not subject to the intergovernmental review requirements of Executive Order
12372 or Health Systems Agency review.
The PHS strongly encourages all grant and contract recipients to provide a
smoke-free workplace and promote the non-use of all tobacco products. In
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking
in certain facilities (or in some cases, any portion of a facility) in which
regular or routine education, library, day care, health care or early
childhood development services are provided to children. This is consistent
with the PHS mission to protect and advance the physical and mental health of
the American people.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
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Department of Health and Human Services (HHS)
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NIH... Turning Discovery Into Health®
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