Release Date:  August 26, 1999

National Institute on Drug Abuse


The purpose of this notice is to inform the research community that the
National Institute on Drug Abuse (NIDA) has clarified its program and review
guidelines for Program Project grants (P01 mechanism). 

NIDA awards Program Project grants for research projects closely related to a
central theme that can be conducted effectively and efficiently through a
coordinated collaborative or multidisciplinary approach using common
resources, facilities, and instruments.  NIDA supports Program Projects of
only the highest quality, and each research project within the P01 award 
must be supportable on its own merit.  The scientific merit of each research
project is assessed independently as well as within the context of the whole

Program projects are expected to be broadly based investigative efforts with a
well defined central focus or objective.  The efforts should address critical
issues of neuroscience, behavior, prevention, treatment, epidemiology,
etiology, health services, or other drug abuse-related research areas.  

Applications will be accepted on an on-going basis.  The receipt dates for all
unsolicited center applications, whether new, competing renewal, or revised,
are February 1, June 1, and October 1.  An applicant requesting $500,000 or
more in direct costs for any year of a center is required to obtain agreement
from the Institute program staff that the Institute is willing to accept the 
application for review and possible funding.  The name of the program contact
must be indicated in a cover letter submitted with the application. 
Applications that do not identify a program contact will be returned to the
applicant without review. 

These guidelines are effective with applications submitted for the February 1,
2000, receipt date.  The Program Project Consolidated Program and Review
Guidelines are available on NIDA's home page ( and
may be obtained from:

National Institute on Drug Abuse
Office of Extramural Program Review
6001 Executive Boulevard, Room 3158
Bethesda,  MD 20892-9547
Telephone:  (301) 443-2755

Applications submitted under these guidelines must be sent to the Center for
Scientific Review at the address noted in the application form PHS-398 (rev.

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