ADMINISTRATIVE SUPPLEMENTS TO ESTABLISH DNA ARRAY FACILITIES Release Date: February 26, 1999 P.T. National Cancer Institute. The National Cancer Institute announces the availability of administrative supplements to institutions with NCI-funded research projects to assist with the purchase of equipment necessary to establish DNA array facilities. The DNA array facilities must be designed to support application of these comprehensive molecular analysis technologies to innovative cancer research. A minimum of five NCI-funded research projects must be served by the activities of the array facility. Institutions with NCI-funded research project (R01), MERIT award (R37), program project (P01), Center Core (P30), Comprehensive Center (P60) or Specialized Center (P50) grants are eligible. The work proposed must be within the scope of the research originally approved by peer-review. Requests for supplements are limited to one per institution. Requests must be limited to the purchase of equipment critical to the DNA array facility. Appropriate equipment for which support can be requested includes, but is not limited to, DNA arrayers, array readers, robotics equipment to facilitate automation, and, with strong justification, computers to support the informatics component of the facility. Applicant institutions will be expected to support the personnel and other costs associated with the establishment and continued activities of the DNA array facilities. Applicants should include in their requests a brief discussion of plans for the administration of the facilities. Discussions should include consideration of how priorities will be set in order to ensure investigators from the institution broad access to the facilities. Where appropriate the facilities may serve not only the applicant institution but also closely collaborating groups or institutions. There is no restriction to the type of array technology that the applicants may select. The NCI intramural program has established a DNA micro-array facility. Successful applicants electing to use this particular technology can request information and assistance helpful in establishing cDNA micro-array facilities in their home institution. NCI will give consideration to supplement requests from all eligible applicants. However, because funds are limited, highest priority will be given to supplement requests that meet the following criteria. 1. The applicant has provided a detailed description of five funded cancer research projects that will benefit from the presence of the array facility. This includes descriptions of how the availability of array technology will enhance ongoing research efforts. Although these descriptions should be as concise as possible, sufficient detail must be provided to allow NCI to judge the merit of the requested supplement. 2. The applicant has provided documentation of the institutional commitment to support the array facility. This includes a commitment of continued support for the facility. Applicants must document how they will support the personnel needed for the effective functioning of the facility. Applicants must also document availability of appropriate laboratory space for the facility. 3. The applicant has provided a detailed description of the equipment requested and has carefully documented and justified the requested budget which may not exceed a total cost of $250,000. The request must be countersigned by the grantee institution�s business office. 4. The applicant has provided a discussion of how the DNA array facilities will be administered. Special attention should be given to setting priorities for the facilities and to ensuring equitable access by the projects discussed in item 1. A request for a supplement under this announcement should be submitted in the form of a letter which includes a detailed budget. The requests are submitted directly to the NCI program director who is responsible for the administration of the grant to be supplemented. The program director is identified on the most recent Notice of Grant Award. Grantees are strongly encouraged to discuss the request with their program directors before submitting. This is a one time announcement with requests submitted on or before May 5, 1999. The request will be evaluated by the program director responsible for the administration of the grant and then evaluated and prioritized by an NCI committee of extramural program staff who have expertise in this scientific area. NCI has set aside $2.5 million to support these supplements. INQUIRIES General inquires relating to this notice should be directed to: James W. Jacobson, Ph.D. Division of Cancer Treatment and Diagnosis National Cancer Institute 6130 Executive Boulevard, Room 700 Bethesda, MD 20892 Telephone: (301) 402-4185 FAX: (301) 402-7819 Email: jj37d@nih.gov
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