Release Date:  December 2, 1998

PA NUMBER:  PA-99-004


National Institute of General Medical Sciences
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Environmental Health Sciences
National Institute of Neurological Disorders and Stroke
National Institute of Mental Health

This notice is an addendum to program announcement PA-99-004, which was released
in the NIH Guide for Grants and Contracts on October 16, 1998.  This PA supports
work leading to atomic level resolution of membrane proteins.


The purpose of this addendum is to add the National Institute of Mental Health
(NIMH) as a participant in this program announcement, to define the research
areas covered by this program announcement that would be appropriate for funding
consideration by the NIMH (see RESEARCH OBJECTIVES), and to identify the NIMH
contacts (see INQUIRIES).


Membrane protein systems of interest to the National Institute of Mental Health
(NIMH) include proteins involved in synaptic transmission, as well as in
regulatory, metabolic, homeostatic, and signaling functions in normal brains, in
'altered' states (such as during stress and during learning and memory), in
disease states, and in the developing nervous system.  These include proteins
involved in vesicle trafficking, in receptor trafficking, in the synthesis,
translocation and/or compartmentalization of cytoskeletal elements in neurons and
glia, in various facets of nervous system development (such as
cytodifferentiation, cell migration, cell adhesion, cell death, dendritic and
axonal development, axonal guidance and pathfinding, synapse formation, axonal
retraction, myelination, etc.) and in neurodegenerative disorders (such as
lysosomal and amygloid dysfunctions), as well as receptors (for neurotransmitters
such as glutamate, GABA, acetylcholine, norepinephrine, serotonin, dopamine,
glycine, peptide neurotransmitters, as well as for hormones, trophic factors, and
other neuromodulators), ion channels (sodium, calcium, potassium, voltage gated,
ligand gated, etc.), transporters, ion pumps, and second messenger systems (G-
proteins, cyclic nucleotides, kinases, phosphatases, phopholipases, etc.).


Program officials and grants management contacts at participating awarding
institutes are listed in the original program announcement.  The following NIMH
contacts should be added to that list.

Direct inquiries regarding programmatic issues to:

Chiiko Asanuma, Ph.D.
Signal Transduction Program
National Institute of Mental Health
5600 Fishers Lane, Room 11C-06
Rockville MD  20857
Telephone:  (301) 443-5288
FAX:  (301) 443-4822

Direct inquiries regarding fiscal matters to:

Diana S. Trunnell
Grants Management Branch
National Institute of Mental Health
5600 Fishers Lane, Room 7C-08
Rockville, MD  20857
Telephone: (301) 443-2805
FAX:  (301) 443-6885

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