STUDIES OF CHEMICAL DISPOSITION IN MAMMALS

Release Date:  September 15, 1998

RFP AVAILABLE:  NIH-ES-98-29

P.T.

National Institute of Environmental Health Sciences

The purpose of this project is to obtain detailed chemical disposition data from
three to six studies per year of selected environmental contaminants or model
compounds per year.  Most of these studies will be required in laboratory rats
and/or mice; however, some studies may be required in other laboratory animals
(rodents or dogs).  Offerors should note that in year one and in subsequent
years, most studies will involve rats (Fischer 344) and/or mice (B6C3F1).  For
costing purposes offerors are to include costs for one study using purebred
beagle dogs purchased from a commercial breeder of laboratory animals in year
one, only.  Most studies will address the disposition of organic chemicals or
environmental contaminants; however, studies of inorganic compounds may also be
requested.  Individual studies may vary in complexity from preliminary
investigations of chemical absorption to detailed studies of all phases of
chemical disposition, toxicokinetics, and metabolism.  The immediate goal of
these studies is to determine more accurately the doses for NTP bioassay studies. 
The long-range goal is the accumulation of data that will permit a better
assessment of structure-activity relationships chemical absorption, metabolism
and disposition in laboratory animals and to better interpret the significance
of these data to man.  This project will cover a five year period.  The
Government estimates that the project will require approximately two professional
person years and three technical person years per contract year.

Release of the RFP is anticipated on or about September 30, 1998 with proposals
due November 20, 1998.  All responsible sources may submit a proposal that will
be considered by the Agency.

INQUIRIES

Requests must reference RFP No. NIH-ES-98-29 and must be directed to:

Howard Hill
Research Contracts Branch
National Institute of Environmental Health Sciences
79 T.W. Alexander Drive, Building 4401 Research Commons
P.O. Box 12874
Research Triangle Park, NC  27709
Telephone:  (919) 541-4971
FAX:  (919) 541-2712

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