Release Date:  June 19, 1998 

RFA:  HG-98-002


National Human Genome Research Institute

Letter of Intent Receipt Date:  August 1, 1998
Revised Application Receipt Date:  December 10, 1998


The purpose of this notice is to inform the scientific community that the
National Human Genome Research Institute (NHGRI) is revising the RFA "Research
Network for Large-Scale Sequencing of the Human Genome", which appeared in the
NIH Guide on January 9, 1998.  NHGRI remains strongly committed to the goal of
completing a high quality, complete sequence of the human genome by the year
2005.  However, recently there has been discussion in the scientific community
of the potential benefit of generating an intermediate "rough draft" sequence by
2001.  During the next three months, NHGRI will be considering this possibility,
and will be addressing questions about the utility of and best strategy to
develop different types of a "rough draft" sequence. By the end of this period,
NHGRI will decide whether to pursue a rough draft and, if so, what
characteristics of that "intermediate product" would make it most useful and
strategically practical.  Once a decision is made, another NIH Guide Notice will
be published to inform prospective applicants about the NHGRI strategy for
obtaining the human genome sequence.  It is expected that this Notice will be
published no later than September 30, 1998.

NHGRI recognizes that, if the scope of the RFA were to change, applicants would
need time to adjust their strategies and to produce preliminary results in
support of their applications.  Therefore, the receipt date for the applications
has been changed from October 9, 1998 to December 10, 1998.  Applications will
be reviewed in March 1999, considered by the National Advisory Council for Human
Genome Research at its May 1999 meeting and awards for the cooperative agreements
that will participate in the Research Network will be made on July 1, 1999.

The receipt date for the letter of intent remains August 1, 1998.  The letter of
intent should include a descriptive title of the overall proposed research, the
name, address and telephone number of the Principal Investigator, the number and
title of this RFA and a list of key investigators and their institution(s) and
projects.  NHGRI recognizes that the nature and perhaps the titles of the
projects may change as a result of any changes in the scope of this RFA that may
be announced.  NHGRI staff plan to contact each investigator submitting a letter
of intent during the period between the submission dates for the letter of intent
and the application to discuss any changes in the RFA.  Any applicant planning
to submit an application for more than $500,000 direct cost MUST contact NHGRI
staff in order for the application to be accepted by NIH.

The letter of intent is to be sent to:
Dr. Jane L. Peterson
Program Director, Large Scale Sequencing
National Human Genome Research Institute
38 Library Drive, Room 614, MSC 6050
Bethesda, MD  20892-6050


Direct inquiries regarding programmatic issues to:

Dr. Jane L. Peterson or Dr. Adam Felsenfeld
Division of Extramural Research
National Human Genome Research Institute
Building 38A, Room 614, MSC 6050
Bethesda, MD  20892-6050
Telephone:  (301) 496-7531
FAX:  (301) 480-2770

Direct inquiries regarding fiscal matters to:

Ms. Jean Cahill
Grants Management Office
National Human Genome Research Institute
Building 38A, Room 613, MSC 6050
Bethesda, MD  20892-6050
Telephone:  (301) 402-0733
FAX:  (301) 402-1951

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