NCI COOPERATIVE HUMAN TISSUE NETWORK NIH GUIDE, Volume 26, Number 1, January 10, 1997 P.T. 34 Keywords: Cancer/Carcinogenesis Biological Resources National Cancer Institute The National Cancer Institute's Cooperative Human Tissue Network (CHTN) provides human tissue for biomedical research. The CHTN provides normal, benign, pre-cancer and cancer tissue. Trained personnel coordinate the retrieval, preservation and delivery of specimens from surgical resection and autopsy. During nine years of operation, the CHTN has supplied more than 100,000 specimens to approximately 600 investigators. Human tissue provided by the CHTN has been utilized for a variety of research projects, such as studies of gene isolation, gene deletion, gene mutation, growth factors, isoenzymes, subcellular organelles, flow cytometry, DNA hybridization and the development of monoclonal antibodies and cell lines. Five member institutions coordinate the collection and distribution of tissues in the US and Canada. Collection, storage and distribution requirements vary with the research approach and tissue type. Studies on M-RNA and labile proteins require snap-frozen surgical tissue stored at ultra-low temperatures. More stable biological molecules allow a wide range of studies on autopsy tissue, including establishing viable tissue cultures and cell lines. Investigators should discuss the tissue requirements for their research, to assure the largest number and range of research specimens. In order for the CHTN to collect and provide quality tissue specimens to meet specific user needs, each investigator is required to complete a detailed tissue request form. This include information about the type and amount of tissue required, tissue preparation, storage, and shipment requirements (e.g., media, snap frozen, sterile). The CHTN makes every effort to tailor collection, storage and shipment to the needs of the investigator. Tissue is provided according to the following priority order: 1. Funded, peer-reviewed investigators, including those from Federal and National laboratories. 2. New investigators and academic investigators developing new research projects. 3. Other investigators. A nominal processing fee of $20 per specimen is charged to cover some of the cost of collecting, preparing, and handling the tissue. In addition, the investigator is responsible for the cost of shipping specimens to his/her laboratory. Application forms will soon be available from the CHTN Internet site at: http://wwwicic.nci.nih.gov/chtn/chtnmain/html. Applications are also available from the division that serves your geographical area: EASTERN DIVISION - The Eastern Division covers the northeast, the area bounded by the western border of Pennsylvania, and the southern border of Maryland and Alaska and Hawaii. University of Pennsylvania Medical Center Philadelphia, PA 19104-4283 Telephone: (215) 662-4570 FAX: 215-614-6554 Email: chtneast@mail.med.upenn.edu MIDWESTERN DIVISION - The Midwestern Division extends from West Virginia and states west of Pennsylvania north to Minnesota and south through Missouri and Canada. The Ohio State University Columbus, OH 43210 Contact: Ms. Carolyn Cordial Telephone: (614) 293-5493 FAX: (614) 293-5851 Email: cordial-1@medctr.osu.edu PEDIATRIC DIVISION - The Pediatric Division operates nationwide. Children's Hospital Columbus, OH 43205 Contact: Ms. Nancy Sachs Telephone: (614) 722-2890 FAX: (614) 722-2897 Email: nsachs@chi.osu.edu SOUTHERN DIVISION - The Southern Division encompasses Kentucky and Virginia and all states south and west of the Carolinas to Texas. University of Alabama at Birmingham Birmingham, AL 35294-0007 Contact: Ms. Katherine Sexton Telephone: (205) 934-6071 FAX: (205) 934-0816 Email: sexton@tp.path.uab.edu WESTERN DIVISION - The Western Division includes the states north of Oklahoma and west of Texas. Case Western Reserve University Cleveland, OH 44106 Contact: Ms. Diane Zorkle Telephone: (216) 844-8538 FAX: (216) 844-8522 Email: dmz2@po.cwru.edu .
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