NIH GUIDE, Volume 26, Number 22, June 27, 1997







National Institute of Allergy and Infectious Diseases


The Opportunistic Infections Research Branch, Therapeutics Research

Program, Division of AIDS, National Institute of Allergy and

Infectious Diseases (NIAID), NIH, has a requirement to develop

therapies for the treatment of AIDS and associated opportunistic

infections.  The purpose of this RFP is to seek responsible offers

for establishment of drug screening capability.  To this end, this

solicitation is to support activities in the microbiological and

animal model testing of new candidate drugs.  Performance of the Work

Statement includes (a) evaluation of therapeutic agents against C.

neoformans in a standardized, validated mouse model of acute

cryptococcal infection of the central nervous system; (b) evaluation

of therapeutic agents against C. neoformans in a standardized,

reproducible and validated in vitro test system employing intact

organisms; and (c) additional studies such as evaluation of drug

combinations, determination of optimal dosages of therapeutic agents,

and evaluation of therapeutic agents in prophylaxis protocols.


It is anticipated that one cost reimbursement, completion type

contract (approximately 2.5 FTEs) will be awarded for a period of

four years, beginning approximately July 23, 1998.  RFP

NIH-NIAID-DAIDS-98-13 will be available electronically on or about

July 20, 1997, and may be accessed through either the NIAID Contract

Management Branch (CMB) Home Page or the NIH Gopher by using the

following electronic addresses and instructions: (1) NIAID/CMB Home

Page (via the World Wide Web): Access by using and select the "RFPs" link.  (2) To

access the NIH Gopher: Point your Gopher client to GOPHER.NIH.GOV

PORT 70 (You should now be in the NIH Gopher).  Select "Grants and

Research Information",  then select "R&D Requests for Proposals

(RFP)".  Please note that the RFP for this procurement has been

revised to include only the Work Statement, deliverable and reporting

requirements, the Technical Evaluation Criteria, and the proposal

preparation instructions.  All information required for the

submission of an offer will be contained in the electronic RFP

package.  Following proposal submission and the initial review

process, offerors comprising the competitive range will be requested

to provide additional documentation to the Contracting Officer.




Responses to this RFP will be due on November 20, 1997.  Any

responsible offeror may submit a proposal that will be considered by

the Government.  This advertisement does not commit the Government to

award a contract.


Joyce U. Sagami

Telephone:  (301) 496-7118

FAX:  (301) 402-0972


No collect calls will be accepted



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