NIH GUIDE, Volume 26, Number 22, June 27, 1997




P.T. 34


  Nervous System 




National Institute on Drug Abuse


The National Institute on Drug Abuse (NIDA), Intramural Research

Program(IRP) is soliciting proposals from qualified organizations

having in-house capability to study spinal cord neuroanatomy,

regeneration, synapse formation, neurotrophic factors, regeneration

of white matter, contusion injuries, improvement of functional

recovery of high spinal cord lesions and contusion injuries.  The

research will build on work published by Drs. Cheng, Cao and Olson in

Science 96.  The project will generate experiments that will

demonstrate novel spinal cord repair strategies.  The contractor will

be required to carry out experiments using multiple (18) fine

peripheral nerve graft bridges across spinal cord lesions, that

reroute and regenerate nerve fibers from white matter to grey matter;

using precisely defined positioning of the nerve grafts and

stabilization of the engrafted area with a fibrin-based tissue glue.

Research will require access to and use of a high resolution MRI that

will allow detailed analysis of structures as small as the rat spinal

cord. In addition to generating a further basis for interpretation of

the repair strategy, the project will study several new aspects such

as whether or not there is an altered conduction across the injured

area as well as aspects of specificity and topography of function of

regenerated fiber tracts.  In addition, chronic spinal cord injury

will be studied.  The contractor must have experience and  expertise

in spinal cord regeneration, synapse formation, fibrin-based tissue

glue, regeneration of white matter and related neurotrophic factors.


It is anticipated that one cost reimbursement, completion or fixed

price type contract will be awarded for a period of two years.


RFP No. N01DA-7-9055 will be available electronically on or about

June 23, 1997, and may be accessed through the NIH Gopher and/or the

Internet by using the following electronic mail addresses and



1.  NIH Home Page (via the World Wide Web): Access the NIH Home Page

by using . Once you are at the NIH Home Page,

select ~Grants and Contracts~; select ~NIH Gopher directory: listed

under the ~Contracts Page~ section.  Once at the NIH R&D Gopher,

select ~RFPs Available~; select ~NIDA~; and select ~RFP N01DA-7-

9055".   (URL: gopher://


2.  NIH Gopher: Point your Gopher client to GOPHER.NIH.GOV Port 70

(you should now be in the NIH Gopher).  Select ~Grant and Research

Information~; select ~R&D Request for Proposals (RFP)~; select ~RFPs

Available~; select ~NIDA~; and, select ~RFP N01DA-7-9055".


Please note that the RFP for this acquisition will be streamlined to

include only the Work Statement, deliverable and reporting

requirements, special requirements and mandatory qualifications,

Technical Evaluation Criteria, and proposal preparation instructions.

All information required for the submission of an offer will be

contained in the electronic RFP package.


Response to this RFP will be due on or about July 23, 1997.  Any

responsible offeror may submit a proposal which will be considered by

the Government.  This advertisement does not commit the Government to

award a contract.




For further information, contact:


Dale S. Weiss, Contracting Officer

National Institute on Drug Abuse

5600 Fishers Lane, Room 10-49

Rockville, MD  20857

Telephone:  (301) 443-1301

FAX:  (301) 443-7595




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