IMMUNOLOGIC FACTORS IN SALIVA AND BLOOD AS DETERMINANTS OFHIV-RELATED DISEASES

 

NIH GUIDE, Volume 26, Number 13, April 25, 1997

 

RFP AVAILABLE:  NIH-NIDR-3-97-9R

 

P.T. 34



Keywords:

  AIDS 

  Immunology 

 

National Institute of Dental Research

 

The National Institute of Dental Research (NIDR) has a requirement to

develop methods and assays for selected immunological and viral

characteristics in the saliva and serum of members of a cohort of

HIV-positive U.S. military personnel.  Approximately 2000 serum and

2000 saliva samples (to be furnished by the Government) will be

tested for total IgG, IgM, and IgA; HIV-specific IgG, IgM, and IgA;

nonspecific immune factors (lactoferrin, lysozyme and

lactoperoxidase); levels of secretory leukocyte protease inhibitor;

quantitative HIV virions; and infectivity of human peripheral blood

mononuclear cells (PBMC).  Special features of this project are the

large number of samples and the need for the development of

procedures to apply to saliva as the matrix and to conserve volume of

specimen as much as possible.

 

It is anticipated that one award will be made as a result of this

solicitation.  The Request for Proposal (RFP) will be available on or

about April 17, 1997, with proposals due on or about June 2, 1997.

 

INQUIRIES

 

Verbal requests for the RFP will not be accepted; requests must be

submitted in writing, addressed to:

 

Marilyn R. Zuckerman

Contracts Management Section

National Institute of Dental Research

45 Center Drive MSC 6402

Bethesda, MD  20892-6402

 

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