IMMUNOLOGIC FACTORS IN SALIVA AND BLOOD AS DETERMINANTS OFHIV-RELATED DISEASES NIH GUIDE, Volume 26, Number 13, April 25, 1997 RFP AVAILABLE: NIH-NIDR-3-97-9R P.T. 34 Keywords: AIDS Immunology National Institute of Dental Research The National Institute of Dental Research (NIDR) has a requirement to develop methods and assays for selected immunological and viral characteristics in the saliva and serum of members of a cohort of HIV-positive U.S. military personnel. Approximately 2000 serum and 2000 saliva samples (to be furnished by the Government) will be tested for total IgG, IgM, and IgA; HIV-specific IgG, IgM, and IgA; nonspecific immune factors (lactoferrin, lysozyme and lactoperoxidase); levels of secretory leukocyte protease inhibitor; quantitative HIV virions; and infectivity of human peripheral blood mononuclear cells (PBMC). Special features of this project are the large number of samples and the need for the development of procedures to apply to saliva as the matrix and to conserve volume of specimen as much as possible. It is anticipated that one award will be made as a result of this solicitation. The Request for Proposal (RFP) will be available on or about April 17, 1997, with proposals due on or about June 2, 1997. INQUIRIES Verbal requests for the RFP will not be accepted; requests must be submitted in writing, addressed to: Marilyn R. Zuckerman Contracts Management Section National Institute of Dental Research 45 Center Drive MSC 6402 Bethesda, MD 20892-6402 .
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