NIDCD RESEARCH AREAS OF SPECIAL EMPHASIS NIH GUIDE, Volume 25, Number 40, November 22, 1996 P.T. 34 Keywords: Communicative Disorders, Hearing Communicative Disorders, Speech National Institute on Deafness and Other Communication Disorders PURPOSE This notice is to inform the scientific community of several areas of research emphasis within the National Institute on Deafness and Other Communication Disorders (NIDCD) and to encourage grant applications seeking support for these areas of research. The NIDCD has primary responsibility for supporting basic, clinical and applied research and research training on normal and disordered mechanisms of hearing, balance, smell, taste, voice, speech and language (i.e., communication disorders). More than 46 million people in the United States suffer from some form of communication disorder. The NIDCD addresses special biomedical and behavioral problems associated with people who have communication impairments or disorders. This notice highlights several of the research areas that have been identified by the Programs Advisory Committee of the NIDCD as opportunities or gap areas in need of research emphasis. Research Goals and Scope I. Application of Emerging Technologies to Human Communication The introduction of new technologies in recent years offers a unique opportunity to apply innovative approaches to basic and clinical investigations of human communication. Areas of research emphasis include, but are not limited to: o Application of advanced imaging technologies - New imaging techniques provide research opportunities for studies of structure and function, diagnostics, treatment and rehabilitation of individuals with communication disorders. Research plans should focus on the development of new imaging techniques and the application of existing imaging techniques to the study of the normal processes of human communication as well as the changes in function that are associated with diseases and disorders of communication. Collaborations among scientific disciplines are encouraged. o Approaches for gene transfer into cells of the inner ear - Advances in gene transfer technology provide the possibility of replacing or enhancing the function of mutated genes in disorders that lead to or predispose the development of inner ear lesions which cause hearing impairment and balance disorders. Initial studies of effective approaches for DNA transfer into cells of the inner ear may include the use of "reporter" genes that produce an easily detectable product. o Application of genetic and molecular approaches to voice, speech and language research - Within this broad area, research topics may include, but are not limited to: cellular and molecular mechanisms underlying critical periods in voice, speech and language development; the role of neurotrophins and growth factors in recovery from brain injury and wound healing; and the application of molecular genetic techniques such as gene linkage analysis and positional cloning strategies to voice, speech and language disorders. o Molecular regulation of receptor subtypes in chemoreceptors - Continuous renewal of chemosensory receptor cells poses a fundamental question of how these systems maintain stable sensory capabilities in the face of sensory cell turnover and subsequent synaptogenesis. Studies are needed to examine the molecular mechanisms that regulate the expression of individual receptor subtypes and to identify signals from the nervous system and/or chemical environment that may influence these processes. II. Prevention and Treatment of Communication Disorders The NIDCD encourages research on the development and evaluation of new approaches for the prevention and treatment of communication disorders. Results of research in these areas will provide a rational basis for designing interventions to improve the quality of life for all individuals with communication disorders. Within this broad area, research topics of emphasis include, but are not limited to: o Pharmacotherapy for individuals with communication disorders - The application of contemporary techniques of molecular and cellular biology is needed for the rational development of effective pharmacotherapeutic agents for the prevention and treatment of communication disorders. Randomized, controlled clinical trials are also needed to determine the efficacy of a variety of pharmacotherapeutic agents for individuals with communication disorders. o Hearing impairment and other communication disorders associated with cytomegalovirus (CMV) infection, human immunodeficiency virus (HIV) infection, and acquired immunodeficiency syndrome (AIDS) - Additional research on these topics will increase understanding of the etiology and pathophysiology of communication impairments resulting from CMV infection, HIV infection, and AIDS. This information is needed to improve treatment and quality of life for HIV-infected individuals. o Neural control of swallowing and dysphagia - Basic and clinical studies will lead to a better understanding of the oral, pharyngeal and laryngeal components of swallowing and dysphagia. The NIDCD encourages studies on the development of instrumentation and imaging techniques to assess the normal swallowing process and its disorders, and the assessment of treatment efficacy including pharmacotherapy, surgery, prosthetic devices, compensatory strategies and behavioral treatment. III. Integrative Neuroscience Integration of various aspects of molecular and cellular biology with function and behavior and the determination of their relationship to disorders of human communication will provide a rational basis for approaches to therapeutic intervention. Emphasis should be placed on integrating findings across two or more levels of biological organization to answer questions directly; previously, answers could only be inferred by combining data obtained from several sources. Examples of areas of emphasis include, but are not limited to: o Computational neuroscience - Computational neuroscience offers new and powerful tools to develop comprehensive and accurate models of neural and behavioral function. Research areas of interest include, but are not limited to: models of ion channels and receptors; biophysical mechanisms in synapses and neurons; simulations of neural circuits or networks; and models of sensory information processing, sensorimotor integration, plasticity, recovery of function, learning, language and memory. o New approaches to investigate higher cognitive functions - Research is needed on the central processing of sensory information leading to higher cognitive functions in communication, such as perception, discrimination, plasticity, multisensory integration, learning, language and memory. Recent progress on receptor mechanisms and transduction events underscores the importance of integrating these findings with more complex behaviors and functions of the whole organism. The ability of sensory systems to preserve and enhance certain types of information and then to transform that information into other coding schemes that lead to perception and interpretation is currently not well understood. Specific questions of interest include, but are not limited to: (1) the failure of specific cognitive mechanisms in language impairment; and (2) the role of cerebral cortical centers receiving vestibular inputs in spatial cognitive functions, such as the perception of verticality and the direction of "heading" (spatial navigation) during locomotion. IV. Development, Repair and Regeneration Research is needed to understand the molecular, genetic and cellular regulatory factors that underlie normal and abnormal development of communication processes. Studies are encouraged to identify mechanisms that regulate differentiation, cell migration, axonal guidance, synaptogenesis and neurogenesis. There is a particular need for investigations aimed at determining how connectivity and synaptic specificity are established in the vestibular pathways. Additional areas of emphasis include: neural plasticity and recovery from injury; critical periods of development; factors that enhance regeneration and repair; and transplantation of neurogenic cell populations. INQUIRIES Applicants that think the topic of an application is within an area of special research emphasis are encouraged to contact the NIDCD. The opportunity to clarify any issues or questions from potential applicants is welcome. All applications will be assigned according to PHS Referral Guidelines and determination of high program priority will be made by NIDCD staff. Direct inquiries regarding programmatic issues to: Dr. Rochelle Small Division of Human Communication National Institute on Deafness and Other Communication Disorders 6120 Executive Boulevard, Room 400-C - MSC-7180 Bethesda, MD 20892-7180 Telephone: (301) 402-3464 FAX: (301) 402-6251 Email: Rochelle_Small@nih.gov .
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