NIH GUIDE, Volume 25, Number 19, June 14, 1996 (See update: NOT-97-011)


P.T. 34


  Grants Administration/Policy+ 


National Institutes of Health


Beginning with the October 1996 receipt date, the National Institutes

of Health (NIH) will no longer consider any A3 or higher amendments

to an application and, regardless of the number of amendments, the

NIH will not accept a revised (amended) application that is submitted

later than two years beyond the date of the receipt of the initial,

unamended application.  The new policy applies to all mechanisms.


Recent NIH data indicate that amended applications constitute more

than one third of all research project grant applications.  The data

also indicate that investigators who receive initial funding based on

an amended application, whether for a new submission (Type 1) or a

competing renewal (Type 2), experience a lower success rate in

subsequent efforts to secure funding for a competing renewal

application, and the probability of subsequent success in the

competing renewal process diminishes with the number of amendments.

We believe that after these three unsuccessful attempts at funding,

it is preferable for all applicants to take a fresh start at their

research plans.  Therefore, the NIH has adopted a policy that limits

the number of amendments to two.  This limit  allows principal

investigators sufficient time to generate preliminary data if it is

required by the reviewers, and to consider new findings in the area

of research.




Questions or comments concerning this policy may be directed to the

Director, Office of Extramural Research at



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