MULTI-INSTITUTIONAL COOPERATIVE AGREEMENTS FOR CLINICAL EVALUATION OFMAGNETIC RESONANCE IMAGING IN BREAST CANCER - ADDENDUM NIH GUIDE, Volume 25, Number 15, May 10, 1996 RFA: CA-96-012 P.T. 34 Keywords: 0715036 Medical/Diagnostic Imaging Instrumentation, Medical National Cancer Institute The National Cancer Institute (NCI) announces the following addendum to the Request for Applications (RFA) CA-96-012 entitled "Multi- Institutional Cooperative Agreements for Clinical Evaluation of Magnetic Resonance Imaging in Breast Cancer," which appeared in the NIH Guide for Grants and Contracts, Vol. 25, No. 12, April 19, 1996: "Recent discoveries have made it clear that mutations in certain genes, such as BRCA1 and BRCA2, can define a population of women having increased genetic susceptibility for the development of breast cancer. The immanent commercial availability of genetic testing in the near future heightens the need to evaluate the effectiveness of new technologies such as breast MRI for the screening of women at increased genetic risk, particularly since it is expected that many women who are found to carry mutations will be in younger age groups, where the sensitivity of conventional film mammographic screening is problematic. In addition to responding to the major focus of this RFA, applicants anticipating access to meaningful numbers of patients with mutations in known breast-cancer genes are strongly encouraged also to propose pilot studies that evaluate the potential role of breast MRI in detecting early breast cancer in women at increased genetic risk." To accommodate applicants who plan to incorporate MRI screening studies of breast cancer in women at increased genetic risk into their response to this RFA, applications also will be accepted on August 27, 1996, in addition to the previously published receipt date of July 30, 1996. INQUIRIES Questions regarding this addendum may be directed to: Dr. Carl Mansfield Division of Cancer Treatment, Diagnosis and Centers National Cancer Institute 6130 Executive Boulevard, Suite 800 - MSC 7440 Bethesda, MD 20892-7440 Telephone: (301) 496-6111 FAX: (301) 480-5785 Email: mansfieldc@dtpepn.nci.nih.gov .
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