NIH GUIDE, Volume 25, Number 14, May 3, 1996




P.T. 34


  Biological Resources 


National Cancer Institute


The National Cancer Institute (NCI), Division of Cancer Treatment,

Diagnosis and Centers (DCTDC), Developmental Therapeutics Program

(DTP) anticipates the award of one cost-reimbursement contract, for a

base period of three years, with two one-year option years, beginning

on or about February 1, 1997.  The objective of this project is to

continue the exploration of marine organisms from the geographic

areas of the globe in which biodiversity is thought to be the

greatest; and to use these organisms as a source of pharmacophores

that can be developed for the selective treatment of cancer and AIDS

in humans.  The successful offeror will be expected to provide

qualified personnel, materials, and equipment for the collection,

identification, storage and shipping of 700 frozen marine samples per

year to an NCI designated extraction facility in the United States.

Collections will comprise approximately 1000 grams frozen, wet weight

of each sample, collected by SCUBA divers at depths to 50 to 55

meters using suitable safeguards.  Each sample will be identified as

far as possible at the time of collection, and will subsequently be

identified to species level. Properly prepared voucher specimens will

be prepared at the time of collection for the purposes of later

unambiguous identification, and for deposition at a minimum of two

repositories identified by the NCI, together with complete

documentation.  The collection team should include qualified

taxonomists, personnel experienced in scientific diving and

collection by SCUBA techniques (to at least 40 meters, but to 50-55

meters if experienced personnel are available).  The Principal

Investigator should be trained in marine biology or a related field

and at least five years experience in marine organism collection and

identification.  It is anticipated that recollection of up to 50

marine samples per year in quantities to 50 kg may be required in the

second and subsequent years.  The number of smaller scale collections

would be reduced in a suitable proportion.  Collections will include

examples from as wide a variety of phyla and families as possible.

The collection will be heavily weighted towards invertebrates with

allowance for a small percentage of marine plants, and with specific

exclusion of vertebrates.  A list of genera and species previously

screened by NCI will be provided with the RFP, in order to aid in the

determination of priorities by the successful contractor.  The

contractor will be responsible for obtaining all necessary permits,

(including visas, shipping and export permits) from foreign

governments and agencies, for deliver of samples and voucher

specimens to the United States.  All collections will be conducted

under the conditions of the NCI's Letter of Collection, which is

provided with the RFP.  Where necessary, the Government will provide

letters of support.  This is a recompetition of a contract with Coral

Reef Research Foundation.




The Request for Proposal (RFP) will be available on or about May 22,

1996.  A copy of the RFP can be obtained by written request to:


Elsa B. Carlton

Research Contract Branch

National Cancer Institute

Executive Plaza South, Room 603

6120 Executive Boulevard - MSC 7220

Bethesda, MD  20892-7220



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