NIH GUIDE, Volume 25, Number 10, March 29, 1996




P.T. 34



  Infectious Diseases/Agents 


National Institute of Allergy and Infectious Diseases


The Opportunistic Infections Research Branch, Therapeutics Research

Program, Division of AIDS, National Institute of Allergy and

Infectious Diseases (NIAID), NIH, has a requirement to develop

therapies for the treatment of AIDS and associated opportunistic

infections.  The purpose of this RFP is to quantitatively evaluate

therapeutic agents for efficacy against Pneumocystis carinii in a

standardized, validated mouse model test system.  In vivo studies

will include evaluation of therapies in combination in the primary

mouse model, drug evaluation in prophylaxis protocols in the primary

mouse model, and evaluation of treatment therapies in a rat model.

Therapeutic agents will be evaluated for efficacy in a standardized,

reproducible and validated in vitro test system which employs intact

organisms.  The offeror should have available a mouse testing system

and an in vitro system (including relevant Pneumocystis strains)

suitable for the evaluation of therapies with potential for treatment

of Pneumocystis carinii infections in people with AIDS.


It is anticipated that one cost reimbursement, level-of-effort type

contract will be awarded for a period of five years beginning on or

about July 10, 1997.  It is estimated that 1,400% total effort will

be needed for this acquisition during the five-year period.


RFP NIH-NIAID-DAIDS-97-04 will be available electronically on or

about April 15, 1996, and may be accessed through either the NIH

Gopher or the NIH Home Page by using the following electronic mail

addresses and instructions:


1) To access the NIH Gopher: Point your gopher client to

GOPHER.NIH.GOV PORT 70.  (You should now be in the NIH Gopher.)

Select "Grant and Research Information," then select "R&D Request for

Proposals" (RFP).


2) NIH Home Page (via the World Wide Web):  Access the NIH Home Page

by using  Once you are at the NIH Home Page,

select "Grants and Contracts," then select "R&D Requests for

Proposals (RFP)."


Responses to this RFP will be due on August 15, 1996.  Any

responsible offeror may submit a proposal which will be considered by

the Government.  This advertisement does not commit the Government to

award a contract.




Inquiries regarding this RFP may be directed to:


Nancy Hershey

Contract Management Branch

National Institute of Allergy and Infectious Diseases

6003 Executive Boulevard, Room 3C07 - MSC 7610

Bethesda, MD  20892-7610

Telephone:  (301) 496-0193

FAX:  (301) 402-0972



No collect calls will be accepted.



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