NEURONAL PRECURSOR CELLS FOR TRANSPLANTATION AFTER CNS TRAUMA 

NIH GUIDE, Volume 25, Number 4, February 16, 1996

 

BAA/RFP AVAILABLE:  NIH-NINDS-96-07

 

P.T. 34



Keywords:

  Nervous System 

  Trauma, Cell Biology 

  Transplantation Immunology 

 

National Institute of Neurological Disorders and Stroke

 

The National Institute of Neurological Disorders and Stroke (NINDS),

NIH will, under a Broad Agency Announcement (BAA)/Request For

Proposals (RFP), solicit proposals for developing methods and

protocols for the isolation, culture, and preparation of progenitor

cells from an adult (animal) nervous system for use as cellular

transplants in CNS trauma.  In addition, the project will support

work to demonstrate the feasibility of transplantation of these cells

into an established animal model of CNS trauma and to show the

survival, phenotype development, and host/graft interactions of the

implanted cells.  The Division of Stroke and Trauma (DST) of the

NINDS supports research related to the amelioration of damage after

CNS trauma.  One area of opportunity for new approaches to this

problem is represented by the potential use of stem cells found

within the adult nervous system as a reservoir of neurons for

transplantation after trauma.  The isolation, tissue culture

conditions, and preparation of these cells for transplantation would

provide useful, basic information to researchers who could then

utilize cells in more applied research on treatment of head or spinal

cord injury, and potentially other diseases.  Offerors will be

required to have appropriate and available research facilities for

isolation, culture, and testing of progenitor cells from adult

(animal) nervous system.  In addition, knowledge of CNS injury

paradigms and ability to perform implantation studies in an animal

model should be at the facility or easily available through defined

collaboration.  Prospective offerors shall be required to obtain

institutional approval for all animal studies and follow the PHS

guidelines for the Care and Use of Laboratory Animals.  Human studies

will not be supported under any resultant contract.  It is

anticipated that one multi-year cost reimbursement type contract will

be awarded for a maximum period of four years.  This is not a Request

for Proposals.  BAA/RFP No. NIH-NINDS-96-07 will be issued on or

about March 1, 1996 with proposals due approximately sixty days

thereafter.

 

INQUIRIES

 

All responsible sources may submit a proposal that will be considered

by the NINDS.  This notice does not commit the NINDS to make any

award under the solicitation.  To receive a copy of the BAA/RFP,

submit a written request and two self-addressed mailing labels to:

 

Kirkland L. Davis

Contracts Management Branch, DEA

National Institute of Neurological Disorders and Stroke 7550

Wisconsin Avenue, Room 901 - MSC 9190

Bethesda, MD  20892

Reference:  BAA/RFP No. NIH-NINDS-96-07

 

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