PRODUCTION OF ANTIBODIES TO NEW CRANIOFACIAL GENES RELEVANT TOANOMALIES AND ORAL CANCERS NIH GUIDE, Volume 25, Number 2, February 2, 1996 RFP AVAILABLE: NLM 96-100/MLM P.T. 34 Keywords: RESEARCH RESOURCES Biological Resources National Institute of Dental Research The National Institute of Dental Research (NIDR) has a requirement to generate a library of antibody reagents for the characterization of novel genes expressed in teeth and craniofacial tissues during embryonic development. Polyclonal antibodies are to be produced in rabbits against purified proteins obtained from selected cDNA clones expressed in E. coli by relatively standard methods. The antibodies are to be evaluated by Western immunoblot analysis and immunocytochemistry for their ability to react with embryonic craniofacial tissues. The project's goal will be to produce a library of approximately 100 characterized antibodies against these novel genes. The Contractor must have experience in recombinant DNA technologies and must demonstrate that they have successfully generated polyclonal antibodies against recombinant proteins previously. The laboratory must be certified by the Federal government as meeting Good Laboratory Practice Regulations (Title 21 of the U.S. Code of Federal Regulations, Part 58) and must be accredited by the American Association for the Accreditation of Laboratory Animal Care (AAALAC) with an assurance statement on file with the Office for Protection from Research Risks (OPRR). It is anticipated that a three-year, cost reimbursement (completion) type contract will be awarded. This project is being initiated by the NIDR. However, the contracts office of the National Library of Medicine (NLM) will be conducting the solicitation. Therefore, all telephone calls and correspondence must be directed to the NLM. INQUIRIES Request for Proposal (RFP) No. NLM 96-100/MLM will be available on or about February 20, 1996, with proposals due on or about April 22, 1996. All responsible sources may submit a proposal, which will be considered by the NIDR. Verbal requests for the RFP will not be accepted; requests must be submitted in writing, addressed to: Lynn Montalvo Office of Acquisitions Management National Library of Medicine Building 38A, Room B1N17 Bethesda, MD 20894 .
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