SMALL BUSINESS INNOVATION RESEARCH PROGRAM NIH GUIDE, Volume 24, Number 33, September 22, 1995 P.T. 34 Keywords: Biomedical Research, Multidiscipl National Institutes of Health Centers for Disease Control and Prevention Agency for Health Care Policy and Research Contract Proposal Receipt Date: December 5, 1995 Innovative technologies and methodologies fuel progress in biomedical and behavioral research and represent an increasingly important area of the economy. The Small Business Innovation Research (SBIR) program provides support for research and development (R&D) of new technologies and methodologies which have the potential to succeed as commercial products. The purpose of this notice is to (1) announce the issuance of the SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH (SBIR) CONTRACT PROPOSALS with a due date for receipt of proposals of December 5, 1995; and (2) inform the public about the opportunities that the SBIR program offers to small business concerns as well as to scientists at research institutions, including colleges and universities. Public Law 102-564, dated October 28, 1992, requires the Public Health Service (PHS), Department of Health and Human Services, and certain other federal agencies to reserve a specified amount of their extramural research or R&D budgets for an SBIR program through fiscal year (FY) 2000. In FY 1996, 2.0 percent of the PHS extramural budget will be reserved for the SBIR program, amounting to $180-$185 million (estimated); and in FYs 1997 and beyond, the set-aside requirement will be 2.5 percent. The offeror organization must be a small business concern, and the PRIMARY EMPLOYMENT of the principal investigator MUST be with the small business concern at the time of award and during the conduct of the proposed project. In accord with the intent of the SBIR program to increase private sector commercialization of innovations derived from federal R&D, scientists at research institutions can play an important role in an SBIR project by serving as consultants and/or subcontractors to the small business concern. Normally, up to one-third of the Phase I budget may be spent on consultant and/or subcontractual costs, and up to one-half of the Phase II budget may be spent on such costs. In this manner, a small business concern with limited expertise and/or research facilities may benefit from teaming with a scientist(s) at a research institution; for the scientist(s) at a research institution, this team effort provides support for R&D not otherwise obtained. The SBIR program consists of the following three phases: PHASE I: The objective of this phase is to determine the scientific and technical merit and feasibility and potential for commercialization of the proposed research or R&D efforts and the quality of performance of the small business concern, before consideration of further Federal support in Phase II. PHASE II: The objective of this phase is to continue the research or R&D efforts initiated in Phase I. Funding shall be based on the results of Phase I and the scientific and technical merit and commercial potential of the Phase II proposal. Only Phase I contractors are eligible to apply for Phase II funding, and Phase II proposals may be submitted upon the request of the Contracting Officer ONLY. PHASE III: The objective of this phase, where appropriate, is for the small business concern to pursue, with non-SBIR funds, the commercialization of the results of the research or R&D funded in Phases I and II. The amount and period of support for SBIR awards are as follows: PHASE I: Awards may not exceed $100,000 for direct costs, indirect costs, and negotiated fixed fee for a period normally not to exceed six months. PHASE II: Awards may not exceed $750,000 for direct costs, indirect costs, and negotiated fixed fee for a period normally not to exceed two years, that is, generally, a two-year Phase II project may not cost more than $750,000 for that project. Only one Phase II award may be made for any SBIR project. Following are the research topics contained in the SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH (SBIR) CONTRACT PROPOSALS: NATIONAL INSTITUTES OF HEALTH NATIONAL INSTITUTE ON AGING (NIA) o Pharmacologic Manipulation of life span: Administration of 2- deoxyglucose to mimic "anti-aging" effects of caloric restriction o Standardized Assessment of Doctor-Older Patient Interactions NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA) o Computer Software for Use in Classifying Alcohol Use Disorders o Markers of Heavy Alcohol Consumption NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK) o Improved Detection Methods for Immunolocalization of Low-Abundance Proteins o Assays for Identification of High Risk Individuals for the Development of Insulin Dependent Diabetes (IDDM) o Transplantation of Human Islets or Beta Cells o Development of Partial Estrogen Agonists With Beneficial Effects on Bone o Gene Therapy for Diseases of Interest to NIDDK o Development of Materials for Screening and Recruitment of Clinical Trial Participants o Self-study Materials for Achieving Intensive Management of Glycemic Levels o Temporal and Spatial Control of Gene Activation/Inactivation o Methods to Detect and Quantify Kidney Damage o Selection and Marking Techniques for Hematopoietic Stem Cells o Expansion of the Numbers of Hematopoietic Stem Cells o Development of New Cytokines NATIONAL INSTITUTE ON DRUG ABUSE (NIDA) o Telemedicine Technology for Drug Abuse and HIV Prevention Research in Community Trials o Development of an Improved HIV Risk Assessment/Monitoring Instrument for Use in Clinical Settings o Software Development of Integrated Research Tools o Drug Supply Services Support o Chemical Libraries for Drug Development o Analytical Services Support NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS) o Development of deuterated nitroso spin traps for identifying xenobiotic free radical metabolites o Development of methodologies for utilization of pathology tissue specimens to obtain information on mechanistic bases of toxicologic responses o Chromosome-specific DNA probes for non-human mammals o Automated scoring of sperm with FISH biomarkers o Development and use of protocols for identifying mutations in mouse cells o Development of subchromosome painting kits for the mouse NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) o Antibodies to HIV-1 gp120: Detection in Formalin-Fixed Human Brain o Kits Combining PCR and Immunocytochemistry: HIV-1 in Human Brain NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS) o Animal Models o Non-Pharmacological Therapy of Epilepsy o Anti-Epileptic Drug Delivery Systems and Formulations o Portable Devices for Sleep Disorder Screening/Monitoring o EEG Home Monitoring for Infants o Near Infrared Spectroscopy (NIRS) for Monitoring of Cerebral Oxygenation o Non-Pharmacological Therapy of Sleep Disorders o Fetal Magnetoencephalography to Assess Fetal Neurological Integrity and Function o Models for Screening Antiepileptic Therapy o Application of Evoked Potentials to the Diagnosis of Sleep Disorders o Development of "Virtual Reality" Goggles and Gloves for use in the Administration of Cognitive Tasks CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) NATIONAL CENTER FOR PREVENTION SERVICES (NCPS) o Develop Technology to Improve AIDS Reporting to State Health Departments o HIV/AIDS Prevention Curriculum PUBLIC HEALTH PRACTICE PROGRAM OFFICE (PHPPO) o Evaluation of Training Impact AGENCY FOR HEALTH CARE POLICY AND RESEARCH (AHCPR) o Consumer Information o Software for Information Capture INQUIRIES Eligibility requirements, definitions, submission procedures, review considerations, contract proposal forms and instructions, and other pertinent information are contained in the SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH (SBIR) CONTRACT PROPOSALS available from: PHS SBIR/STTR Solicitation Office 13687 Baltimore Avenue Laurel, MD 20707-5096 Telephone: (301) 206-9385 FAX: (301) 206-9722 Email: a2y@cu.nih.gov In addition, the Solicitation is available electronically using Business Gold, the National Technology Transfer Center's bulletin board system. Connect via Internet by telneting to "iron.nttc.edu" or by dialing (304) 243-2560 for high speed modems (9600+) or (304) 243-2561 for 1200-2400 baud modems and logging in as "guest". For more information on their electronic bulletin board system, contact: National Technology Transfer Center Wheeling Jesuit College 316 Washington Avenue Wheeling, WV 26003-6295 Telephone: (800) 678-6882 (toll-free within U.S.) Anyone interested in the PHS SBIR Grant program may obtain the current edition of the OMNIBUS SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH (SBIR) GRANT APPLICATIONS from the above sources also. See also the NIH Guide for Grants and Contracts, Vol, 24, No. 3, January 27, 1995. .
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