EVALUATION OF THE POTENTIAL OF 50/60 HZ MAGNETIC FIELDS IN PROMOTINGBREAST CANCER IN DMBA-TREATED FEMALE SPRAGUE DAWLEY RATS



NIH GUIDE, Volume 24, Number 20, June 2, 1995



RFP AVAILABLE:  NIH-ES-95-31



P.T. 34



Keywords:

  Toxicology 

  0715036 

  Health, Radiation Effects 



National Institute of Environmental Health Sciences



The National Institute of Environmental Health Sciences (NIEHS) is

soliciting proposals for studies designed to evaluate the potential

of 50 Hz magnetic fields to promote mammary gland carcinogenesis in

Sprague Dawley rats initiated with dimethylbenzanthracene (DMBA).

The purpose of a 13-week study will be to replicate the series of

studies reported by Loscher, that 50 Hz magnetic fields have the

potential to increase the breast cancer rate in DMBA-treated female

Sprague Dawley rats.  The animals will be exposed to four weekly

intragastric doses (5 mg/animal) of DMBA and magnetic fields of

specified intensities and frequencies.  The purpose of a 26-week

study will be to determine whether or not 50 or 60 Hz magnetic fields

can promote cancer in a standard DMBA model.  The animals will be

exposed to one intragastric exposure (10 mg/animal) of DMBA followed

by exposures to 50 and 60 Hz magnetic fields of specified intensities

for 26 weeks.  This project may have three options:  a 13-week study,

a 26-week study, and a combination study where the 13- and 26-week

studies are run concurrently.  This project will be separated in two

phases.  Phase 1 will be the development phase, during which will

occur the procurement of equipment and materials for the

construction/renovation of the exposure and monitoring systems and

the development effort needed to determine that the system functions

appropriately.  Phase 2 will be the initiation/promotion studies

where one of the three options will be exercised.  It is estimated

that Phase 1 will require approximately 1.04 professional

person-years per contract year and 0.24 technical person-years per

contract year. Phase 2 will require approximately 1.9 professional

person years and 3.4 technical person years for the 13-week study and

2.9 professional person-years and 5.5 technical person-years for the

26-week study.  The estimated period of performance is 17 months.



INQUIRIES



Requests must reference Request for Proposals (RFP) No. NIH-ES-95-31.

All responsible sources may submit a proposal that will be considered

by the Agency. Requests for the RFP are to be directed to:



Jo Ann Lewis

Contracts and Procurement Management Branch

National Institute of Environmental Health Sciences

79 T.W. Alexander Drive, Building 4401 Research Commons

P.O. Box 12874

Research Triangle Park, NC  27709

Telephone:  (919) 541-7893

FAX:  (919) 541-2712



.


Return to 1995 Index

Return to NIH Guide Main Index


Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS)
  USA.gov - Government Made Easy


Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.