NIH GUIDE, Volume 24, Number 8, March 3, 1995

P.T. 34



  Chemical Synthesis 



National Institute of Child Health and Human Development

One program description for the Omnibus Solicitation of the Public

Health Service for Small Business Innovation Research (SBIR) Grant

and Cooperative Agreement Applications (PHS 95-3) was inadvertently

omitted.  The text, as it appears under the heading "B.

Contraceptive Development" pertains to "C. Contraceptive and

Reproductive Evaluation".  Thus, on page 63, under "Contraceptive

Development", the text should read as follows:

B.  Contraceptive Development

Research focussed on new and improved methods of fertility

regulation, for men and for women, that are safe, effective,

inexpensive, reversible, and acceptable.  The objective of the

research is to develop an array of methods that couples in various

population groups can use successfully and safely.

(1) Synthesis and testing of drugs that can influence male and female

fertility and that have the potential of becoming useful


(2) Development of methods of contraceptive drug administration that

can improve the bioavailability from different routes of


(3) Isolation of antigens specific to the reproductive system that

could be utilized for antifertility vaccine development.

(4) Development of improved barrier contraceptives for men and women,

including new spermicidal agents or new formulations that may reduce

vaginal irritation and provide better protection against sexually

transmitted diseases.

(5) Development of simplified methods to quantify sperm counts,

particularly for men with low sperm counts.

(6) Developing leads to non-peptide GnRH analogs (agonists and

antagonists), as potential contraceptive agents, via screening of

libraries of compounds against the GnRH receptor.

C.  Contraceptive and Reproductive Evaluation


For further information regarding this program, contact:

Ms. Hildegard Topper

National Institute of Child Health and Human Development

Building 31, Room 2A03

Bethesda, MD  20892-2425

Telephone:  (301) 496-0104

FAX:  (301) 402-1104



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