EVALUATION OF CHEMOPREVENTIVE AGENTS BY IN VITRO TECHNIQUES NIH GUIDE, Volume 23, Number 45, December 23, 1994 MAA AVAILABLE: NCI-CN-55079-63 P.T. 34 Keywords: Chemoprevention National Cancer Institute The Chemoprevention Branch, Division of Cancer Prevention and Control (DCPC), National Cancer Institute (NCI), in its annual requirement to seek new sources, is soliciting proposals for the Evaluation of Chemopreventive Agents by In Vitro Techniques to increase the number of Master Agreement (MA) Holders. Current MA Holders for this program are not required to submit a proposal. This Master Agreement Announcement (MAA) is issued to solicit MA Holders who have adequate capabilities and technical expertise to screen and evaluate the activity of chemopreventive agents in various in vitro assays of cell transformation. Agents with potential chemopreventive activity are identified by epidemiologic surveys, initial laboratory (experimental) findings, observations in the clinical setting, or structural homology with agents having known chemopreventive activity. A rigorous and systematic evaluation of these candidate agents is necessary before their efficacy can be examined in clinical trials for cancer prevention. In vitro screening and evaluation techniques measuring the ability of these chemopreventive agents to inhibit transformation provides a relatively rapid and efficient means of qualifying these agents for further evaluation for the prevention of cancer in humans. Some of the agents to be used in this project are potentially hazardous. The in vitro systems may involve the use of carcinogens, tumor cells, or tumor viruses. Laboratory practices will be employed that will keep any element of risk to personnel at an absolute minimum. Where indicated, tissue and compound handling must be performed in (at least) Class I laminar flow cabinets, which must meet NIH specifications for work with these agents. The offeror will comply with NCI safety standards for research involving chemical carcinogens (DHHS Publication No. NIH 76-900). It will be required that the facilities have operating tissue culture/cell biology and chemistry laboratories that are suitable for using hazardous and/or carcinogenic materials as test materials. The contractor must have or be able to obtain all equipment necessary to accomplish the studies including, but not limited to, laminar flow hoods, CO2 incubators, equipment for sterility testing, isotope counters, spectrophotometer, hazardous chemical storage cabinets and refrigerators, equipment such as microscopes and miscellaneous laboratory equipment. The laboratory must have or have access to appropriate terminal and computer facilities and equipment for data collection and storage. The period of performance of the Master Agreement (MA) pool will be three years. It is estimated that up to four Master Agreement Orders per year will be issued to the Master Agreements. INQUIRIES Requests for this solicitation must be in writing and reference MAA No. NCI-CN-55079-63. The MAA will be available approximately January 9, 1995 and due approximately February 10, 1995. Requests are to be addressed to: Ms. Tina Huyck Research Contracts Branch, PCCS National Cancer Institute 6120 Executive Boulevard MSC 7226 Bethesda MD 20892-7226 Telephone: (301) 496-8603 .
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