ANIMAL MODELS OF HUMAN VIRAL INFECTIONS FOR EVALUATION OFEXPERIMENTAL THERAPIES



NIH GUIDE, Volume 23, Number 43, December 9, 1994



RFP AVAILABLE:  NIH-NIAID-DMID-96-06



P.T. 34



Keywords:

  Viral Studies (Virology) 

  Disease Model 



National Institutes of Allergy and Infectious Diseases



The Antiviral Research Program of the Virology Branch of the Division

of Microbiology and Infectious Diseases, National Institutes of

Allergy and Infectious Diseases (NIAID) is seeking investigators to

employ appropriate animal model systems of human viral infections to

evaluate the efficacy of antiviral therapies and provide basic

information on the natural history and pathogenesis of viral

infections.  The primary objective of these Animal Models will be to

evaluate experimental therapies for potential clinical efficacy and

toxicity in animal models of clinically important human viral

infections.  In addition, the animal models are used to study disease

pathogenesis and host response to infection.  When appropriate, these

models will also be used for a limited amount of vaccine evaluation

and pharmacokinetic studies.  Basic studies on model development will

be encouraged as an adjunct to the primary focus on therapeutic

evaluation.  Models for cytomegalovirus, herpes simplex, respiratory

syncytial virus, and influenza infections are a priority for NIAID,

but offerors are also encouraged to propose models for other viral

infections as well, except models for retrovirus, hepatitis B and D,

and papillomavirus infections.  Request for Proposals (RFP) NIH-

NIAID-DMID-96-06 will be available on or about December 19, 1994 and

proposals will be due at COB on April 10, 1995.  It is anticipated

that up to five cost reimbursement, completion type contracts will be

awarded for a period of five years.



INQUIRIES



Interested organizations should request either a streamlined or full

RFP package.  If no selection is made, a streamlined version of the

RFP will be provided, which includes only the Statement of Work,

deliverables and reporting requirements, special requirements and

mandatory qualifications, if any, and the Technical Evaluation

Criteria.  After examination of these documents, any organization

interested in responding to the RFP must request the entire RFP in

writing, by telephone, or by FAX request.  This advertisement does

not commit the Government to award a contract.  To receive a copy of

this RFP, supply this office with one self-addressed mailing label.

Telephone inquiries will not be honored and all inquires must be in

writing and addressed to:



Mr. Frank Murphy

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

6003 Executive Boulevard MSC 7610

Bethesda, MD  20892-7610



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