POTENTIAL FOR ENVIRONMENTAL AND THERAPEUTIC AGENTS TO INDUCEIMMUNOTOXICITY NIH GUIDE, Volume 23, Number 40, November 18, 1994 RFP AVAILABLE: NIH-ES-95-22 P.T. 34 Keywords: Toxicology Immunology Environmental Effects National Institute of Environmental Health Sciences The National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), is soliciting proposals from offerors that have the capabilities and facilities to perform the following tasks: Task I, demonstrate proficiency in the performance of the Immune Testing Assays provided by the Environmental Immunology and Neurobiology Section (EINS) to detect chemical-induced immune alteration. The sub-task I-A Immunosuppression will involve Immunopathology, Humoral Mediated Immunity, Cell Mediated Immunity, Cell Quantification, Non-specific Immunity and Host Resistance Assays and sub-task I-B Hypersensitivity Assays will involve Mouse ear swelling test (MEST) and Local lymph node assay (LLNA). Task II-A, upon demonstration of proficiency, the contractor will test four xenobiotics per year using tests described in Task I-A. Task II-B, the contractor will test two xenobiotics per year thereafter. Task II-C the contractor will test two xenobiotics per year for their potential to produce skin hypersensitivity in the mouse. Task II-D, the contractor will test one xenobiotic per year for the potential to influence autoimmune disease. Task III - Development and/or Evaluation of New and Improved Technology will be conducted beginning in year two of the contract, e.g., to quantitate certain biomedical changes. The Government estimates that the project will require approximately 1.5 professional person-years, 1.8 senior technical person years and 1.0 technical person years per contract year. The estimated period of performance is five years. INQUIRIES All responsible sources may submit a proposal that will be considered by the Agency. Release of Request for Proposals (RFP) No. NIH- ES-95-22 is anticipated on or about November 9, 1994 with proposals due January 3, 1995. Requests must reference the RFP number and must be directed to: Howard Hill Contracts and Procurement Management Branch National Institute of Environmental Health Sciences 79 T.W. Alexander Drive, Building 4401 Research Commons P.O. Box 12874 Research Triangle Park, NC 27709 Telephone: (919) 541-4971 FAX: (919) 541-2712 .
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