NIH GUIDE, Volume 23, Number 40, November 18, 1994


P.T. 34


  Infectious Diseases/Agents 


National Institute of Allergy and Infectious Diseases

The Respiratory Diseases Branch and Enteric Diseases Branch, Division

of Microbiology and Infectious Diseases, National Institute of

Allergy and Infectious Diseases (NIAID) have a requirement for two

Mucosal Pathogens Research Units (MPRU).  These MPRUs will conduct

basic research on host-pathogen interactions at mucosal surfaces,

methods to maximize a protective mucosal immunity through the design

of attenuated vectors or delivery systems, as well as Phase I and

Phase II clinical trials to evaluate candidate vaccines and vaccine

strategies and other preventive measures for infectious diseases of

the enteric or respiratory systems.  An MPRU provides volunteer

populations, staff, facilities, and expertise to carry out such work

that includes follow-up and focused epidemiologic-based studies.  A

variety of vaccine types (live-attenuated, inactivated, genetic,

subunit, conjugated) for prevention of viral and bacterial illnesses

are expected, as are vaccine strategies (use of adjuvants or delivery

vehicles) designed to induce protective mucosal immunity.

It is anticipated that two cost-reimbursement, level-of-effort type

contracts will be awarded for a period of seven years.  Of these two

anticipated awards, one award is anticipated for an MPRU that will

focus on enteric pathogens, and one award is anticipated for an MPRU

that will focus on respiratory pathogens.

The streamlined version of RFP NIH-NIAID-DMID-96-07 will be available

on or about December 22, 1994 electronically through the NIH Gopher

and Internet using the following electronic mail addresses and


1.  To access the NIH Gopher: Point your gopher client to


2.  To access the NIH Grant Line (Internet):  Configure your terminal

emulator as:  1200 or 2400 baud, even parity, 7 data bits, 1 stop

bit, Half Duplex.  Using the procedure specified in your

communication software, dial 1-301-402-2221.  When you get a response

indicating that you have been connected, then type  ,GEN1  (the comma

is mandatory) and press ENTER; you will be prompted by the NIH system

for "INITIALS?".  Type  BB5  and press ENTER.  You will then be

prompted for "Account?".  Type  CCS2  and press ENTER.

Please note that the RFP for this procurement has been streamlined to

include only the Work Statement, deliverable and reporting

requirements, special requirements and mandatory qualification, if

any, the Technical Evaluation Criteria, and proposal preparation

instructions.  All information required for the submission of an

offer will be contained in the streamlined RFP package.  Following

proposal submission and the initial review process, offerors

comprising the competitive range will be requested to provide

additional documentation (e.g., Representations and Certifications)

to the Contracting Officer.  PAPER COPIES OF THIS RFP WILL NOT BE



Any responsible offeror may submit a proposal that will be considered

by the Government.  Responses to this RFP will be due on April 14,

1995.  This advertisement does not commit the Government to award a

contract.  Inquiries regarding this RFP may be directed to:

Anthony Murray

Contracts Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

Bethesda, MD  20892

Telephone:  (301) 496-6424


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