STUDIES TO EVALUATE THE TOXIC AND CARCINOGENIC POTENTIAL OF SELECTEDCHEMICALS IN LABORATORY ANIMALS VIA INHALATION



NIH GUIDE, Volume 23, Number 33, September 16, 1994



RFP AVAILABLE:  NIH-ES-94-46



P.T.





Keywords:



National Institute of Environmental Health Sciences



The purpose of this contract is to evaluate the toxic and carcinogenic

potential of selected chemicals of interest.  Exposure to these test

chemicals is via inhalation.  This project includes two year studies of

vanadium pentoxide and napthalene, prechronic and two year studies of

propylene glycol mono-t-butyl ether, decalin and tetralin.  The base

contract award shall include work activities associated with the

development of generation and monitoring methods, as well as health and

safety concerns along with 14-day studies of decalin, propylene glycol

mono-t-butyl ether, and tetralin.  The Government may, pending the

availability of funds, exercise options for:  a 14-day study of

vanadium pentoxide; a 54-day study of naphthalene; 90-day studies of

decalin, propylene glycol mono-t-butyl ether, and tetralin; two year

studies of vanadium pentoxide, napthalene, decalin, propylene glycol

mono-t-butyl ether, and tetralin; and a special 90-day study of

vanadium pentoxide.  These studies shall be conducted according to the

Specifications for the Conduct of Studies to Evaluate the Toxic and

Carcinogenic Potential of Chemical, Biological and Physical Agents in

Laboratory Animals for the National toxicology Program" dated August

1992, with subsequent revisions.  Award of one cost-reimbursement,

completion type contract with an estimated period of performance for

the base contract of approximately eight months on an open competition

basis is contemplated as a result of this solicitation.  Exercise of

all options under this solicitation could result in a multi-year cost

reimbursement type contract with a total term of four years five

months.



INQUIRIES



Interested organizations should request either a streamlined or full

RFP package.  If no selection is made, a streamlined version of the RFP

will be provided, which includes only the Statement of Work,

deliverables and reporting requirements, special requirements and

mandatory qualifications (if any), and technical evaluation criteria.

After examination of these documents, any organization interested in

responding to this RFP must request the entire RFP in writing or by

telephone (919) 541-0416 or by telefax request (919) 541-2712.  All

responsible sources may submit a proposal that will be considered by

the Agency.  Expected release date of the RFP is September 19, 1994

with proposals due November 3, 1994.  Requests must reference RFP No.

NIH-ES-94-46 and are to be forwarded to:



Marilyn B. Whaley

Contracts and Procurement Management Branch, OM

National Institute of Environmental Health Sciences

79 T.W. Alexander Drive, 4401 Building

P.O. Box 12874

Research Triangle Park, NC  27709



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	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)
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