NIH GUIDE, Volume 23, Number 33, September 16, 1994




National Heart, Lung, and Blood Institute

The National Heart, Lung, and Blood Institute (NHLBI) is soliciting

proposals from organizations/institutions to serve as clinic units in

a multicenter trial to determine the effects of psychosocial

interventions on morbidity and mortality in coronary heart disease

(CHD) patients.  The primary objective of this multicenter trial is to

evaluate the effects of psychosocial interventions on the

cardiac-related morbidity and mortality of MI patients at high

psychosocial risk.  High psychosocial risk is defined as the presence

of depression and/or social isolation.  The study design will compare

a psychosocial intervention group, in which patients are provided with

social support and psychological treatment designed to decrease social

isolation and depression, with a health education control and a

standard medical care group, using a combined endpoint of CHD death

plus reinfarction. Secondary endpoints include health-related quality

of life; adherence to medications and health-promoting behaviors; and

ischemic events, measured by ambulatory electrocardiogram and exercise

tolerance testing.  To accomplish its objective, this program proposes

to award approximately eight clinical units for patient accession,

intervention, and data collection.  It is anticipated that a total of

3,000 patients, or approximately 375 patients shall be enrolled per

clinical unit.  The period of performance is anticipated for six years

beginning in August 1995.  The Request for Proposal (RFP)

NHLBI-HC-94-28 is available and proposals are due November 18, 1994.

Offerors other than continental North American institutions will not be

considered based on the need for scientifically comparable data.


All requests for this solicitation must be submitted in writing; oral

requests must be confirmed either in writing or by FAX.  Written

requests must include three self-addressed mailing labels, cite RFP

NHLBI-HC-94-28, and be sent to:

Cheryl A. Jennings

Division of Extramural Affairs

National Heart, Lung, and Blood Institute

7550 Wisconsin Avenue, Room 3C16

Bethesda, MD  20892


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