NIH GUIDE, Volume 23, Number 29, August 5, 1994


P.T. 34


  Physiological Controls and System 

  Prosthetic Device, Heart 

  Cardiovascular System 

National Heart, Lung, and Blood Institute

The Bioengineering Section, Heart Program, Division of Heart and

Vascular Diseases, National Heart, Lung, and Blood Institute (NHLBI)

has an interest in encouraging innovation in the development of totally

implantable ventricular assist systems that are designed to achieve at

least a five-year lifetime with 90 percent reliability.  It is

anticipated that the proposed systems will incorporate the latest

advances in our understanding of circulatory support requirements,

materials science, physics and bioengineering, biocompatibility,

quality control, and manufacturing.  It is expected that this five-year

research and development program will be a multi-disciplinary effort

and that offerors will include in their proposals theoretical bases for

new and improved concepts; mathematical, computer, and physiological

modeling; in vitro and animal testing of prototype systems; human

fitting studies; evaluation of the biocompatibility of candidate

materials; system monitoring; device maintenance; device replacement;

environmental issues; and quality control. This solicitation is not

intended to support formal device readiness testing nor is it intended

to support human subject experimentation.  However, the outcome of this

program should be the availability of one or more ventricular assist

systems that may be considered for future clinical studies.  Four to

six awards are anticipated.  These incrementally funded contracts will

be awarded for five years.  This is not a Request for Proposals (RFP).

RFP NHLBI-HV-94-25 will be released on or about August 3, 1994, with

proposals due December 2, 1994.


Written requests must include three self-addressed mailing labels and

cite RFP NHLBI-HV-94-25.  FAX requests will be accepted.  Requests for

copies of the RFP are to be sent to:

Sharon M. Kraft

Contracts Operations Branch

National Heart, Lung, and Blood Institute

7550 Wisconsin Avenue MSC 9070

Federal Building, Room 4C04

Bethesda, MD  20892-9070

FAX:  (301) 496-9501


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