SYNTHESIS AND DEVELOPMENT OF NEW SPERMICIDES WITH MICROBICIDALPROPERTIES



NIH GUIDE, Volume 23, Number 24, June 24, 1994



RFP AVAILABLE:  NICHD-CD-94-14



P.T. 34



Keywords:

  Contraceptives 

  Microbiology 

  Chemistry, Organic 

  Chemical Synthesis 



National Institute of Child Health and Human Development



The Contraceptive Development Branch of the Center for Population

Research, National Institute of Child Health and Human Development, is

interested in stimulating investigations into the synthesis, testing,

and development of novel spermicidal\anti-STD agents that inactivate

human sperm and sexually transmitted disease (STD) pathogens,

especially HIV, preferably via mechanisms other than the disruption of

cell membranes.  The spermicidal\anti-STD agent is defined as (1) an

agent comprised of a single chemical entity possessing both spermicidal

and anti-STD activity or (2) an agent that is comprised of two chemical

entities, one possessing spermicidal activity and the other anti-STD

activity.  The goals are to obtain human spermicidal\anti-STD agents

that (a) are equipotent with or more potent than nonoxynol-9 (N-9), (b)

have a rapid onset of sperm inactivation equivalent to or greater than

that of N-9, (c) do not cause vaginal irritation, (d) can inactivate

STD pathogens while producing only a transient effect on normal human

vaginal flora, (e) are miscible with human cervical mucus, (f) are

inexpensive, and (g) are aesthetically pleasing (i.e., colorless,

odorless).  Such investigations will involve the synthesis and

biological evaluation of the spermicidal\anti-STD agents by the

contractor.



This project requires both the expertise of a Ph.D. synthetic organic

or medicinal chemist and a Ph.D. biologist.  A collaborative effort

(in-house or via subcontract arrangement) of such scientists is

essential for the success of the project.  Organizations must have

adequate facilities to carry out the proposed syntheses and biological

testing.  The Government estimates the effort to be approximately 4.0

technical person-years annually.  The principal investigator or

co-principal investigators should devote approximately 20 percent

effort to this project.



All responsible sources may submit a proposal that will be considered

by the agency.  It is anticipated that five cost-reimbursement

incrementally funded type contracts will be awarded as a result of the

Request for Proposals (RFP) for a period of 36 months, beginning April

3, 1995.  This announcement is not an RFP.  RFP No. NICHD-CD-94-14 will

be available on or about June 30, 1994.  Proposals will be due

approximately 90 days thereafter.



INQUIRIES



Requests for the RFP must cite the above RFP number.  Copies of the RFP

may be obtained by sending a written or FAX request to:



Paul J. Duska

Office of Grants and Contracts

National Institute of Child Health and Human Development

6100 Building, Suite 7A-07

Bethesda, MD  20892

FAX:  (301) 402-3676



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