DETERMINATION OF PROTECTIVE LEVELS OF MATERNAL ANTIBODY AGAINST EARLYONSET INVASIVE GROUP B STREPTOCOCCAL DISEASE IN NEONATES NIH GUIDE, Volume 23, Number 8, February 25, 1994 RFP AVAILABLE: NICHD-DESPR-94-06 P.T. 34 Keywords: Immunotherapy Infectious Diseases/Agents National Institute of Child Health and Human Development The National Institute of Child Health and Human Development (NICHD) plans to conduct a study that will recruit two groups of infants <7 days of age: infants who have developed invasive GBS (Type Ia, Ib, II and III) disease ("cases"), and infants who have not developed early onset GBS despite being born to GBS-colonized mothers ("controls"). GBS disease will be defined as an infection associated with isolation of GBS from normally sterile sites, such as cerebrospinal fluid and blood. A total of 240 cases and 960 controls will be recruited from participating hospitals over a period of two years. Cases will be identified by active laboratory-based surveillance, and controls will be identified through a systematic culturing of about five percent of parturient mothers in the participating hospitals. To be eligible, both cases and controls must be singleton births of at least 34 weeks' gestation, born to mothers who have not received antibiotic treatment during pregnancy. This Request for Proposals (RFP) for the detection of GBS is a new acquisition. The release of the RFP will be on or about March 1, 1994 and proposals will be due 60 days thereafter. INQUIRIES A short-form version of the RFP will be provided first, which includes only the Statement of Work and Evaluation Criteria to be used for selection of the awardee. After examining this, a full-text version of the RFP must be requested, in writing, for those organizations interested in responding. Those organizations desiring a copy of the above short-form RFP may send their written request to: Mrs. Lynn Salo Office of Grants and Contracts National Institute of Child Health and Human Development 6100 Building, Room 7A07 Bethesda, MD 20892 All requests must cite the RFP number above and include two self- addressed mailing labels for the short-form and complete RFP. All sources who consider themselves qualified are encouraged to submit a proposal. This announcement does not commit the Government to awarding a contract. .
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