NIH GUIDE, Volume 23, Number 7, February 18, 1994




National Cancer Institute

The National Cancer Institute (NCI) is seeking contractors qualified

to perform Phase II Clinical Trials that are small short-term,

efficient studies of potential chemopreventive agents.  This work

includes small, short-term, efficient studies to determine the dose

of a given chemopreventive agent that exhibits a pharmacodynamic

effect on an intermediate endpoint.  These studies will also require

dose response studies to determine the minimum dose at which a

biological effect is observed and confirmation of the maximum safe

dose, and the performance of randomized blinded trials in small

groups of subjects whose endpoints will be the measurable biological

effect of the agent versus a placebo.  This solicitation is an annual

announcement to expand a current pool of Master Agreement (MA)

Holders qualified to perform this type of work.  Individual work

requirements will be defined, as the need arises, by Master Agreement

Orders issued during the period of performance, and Master Agreement

Orders will be awarded based on competition between members of the MA

pool.  The solicitation will be released on or about February 22,

1994, with proposals due April 22, 1994.


The Contracting Officer for this solicitation is Richard L. Hartmann

on telephone (301) 496-8603.  Copies of the RFP may be obtained by

sending a written request to:

Ms. Desiree Sylver-Foust

Research Contracts Branch

National Cancer Institute

Executive Plaza South, Room 635

Bethesda, MD  20892

Telephone:  (301) 496-8603


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