PHYSICAL ACTIVITY INTERVENTION IN HEALTH-CARE SETTINGS FOR HIGH-RISKSEDENTARY ADULTS - COORDINATING CENTER



NIH GUIDE, Volume 23, Number 4, January 28, 1994



RFP AVAILABLE:  NHLBI-HC-94-07



P.T.





Keywords:



National Heart, Lung, and Blood Institute



The National Heart, Lung, and Blood Institute (NHLBI) is soliciting

proposals for a Coordinating Center to participate in a multicenter

clinical trial designed to develop and evaluate the effectiveness of

various intervention approaches delivered in health-care settings in

increasing and maintaining physical activity and cardiorespiratory

fitness among sedentary men and women at elevated risk of coronary

heart disease (CHD) by blood pressure (BP) or lipoprotein criteria.

The study will also examine the cost-effectiveness of the various

intervention approaches as well as the magnitude of effects on BP,

lipoproteins, and weight and the long-term maintenance of those

effects.  In addition to one Coordinating Center to be awarded under

RFP No. NHLBI-HC-94-07, an estimated total of three clinical center

contracts will be awarded under a separate RFP.



The Coordinating Center will have responsibility for the overall

coordination, monitoring, and central management of all activities,

including data entry and management, quality control, data analysis,

and collaborative development of the study protocol, manual of

operations, interventions, and data collection procedures.  The

Coordinating Center will also be charged with the responsibility of

competitively selecting a Central Blood Laboratory to perform as a

subcontract to the Coordinating Center after contract award.  A

planned total of 810 adult subjects will be randomized into three

intervention groups and one comparison group.  This will be a five

year study with a projected award date of September 30, 1994.  The

primary study outcomes will be cardiorespiratory fitness (i.e.,

maximum oxygen uptake) and physical activity (frequency, intensity,

duration, and estimated caloric expenditure).  Because of the need

for scientifically comparable data in a defined population and

relevance to the U.S. health care system, offerors other than U.S.

institutions will not be considered.  This procurement will be a new

award and is open to all offerors who meet the determination of

responsibility as defined by FAR 9.104.



INQUIRIES



Request for Proposals (RFP) No. NHLBI-HC-94-07 is now available.

Letters of Intent will be due two weeks after the release date of the

RFP.  Proposals will be due on March 21, 1994.  All requests for this

RFP must be submitted in writing, verbal requests will not be

accepted.  Written requests must reference RFP No. NHLBI-HC-94-07,

include three self-addressed mailing labels, and be addressed to:



John C. Taylor

Contracting Office

National Heart, Lung, and Blood Institute

7550 Wisconsin Avenue

Federal Building, Room 200

Bethesda, MD  20892

Telephone:  (301) 496-9655



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