SURFACE MODIFICATION FOR BIOCOMPATIBILITY NIH GUIDE, Volume 23, Number 4, January 28, 1994 RFP AVAILABLE: NIH-NINDS-94-04 P.T. Keywords: National Institute of Neurological Disorders and Stroke The Neural Prosthesis Program of the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, is seeking a contract to create surfaces on implantable silicon microstructures for the purpose of controlling the interaction of neurons, glia, and related cells and their protein products with the microstructure. Biomaterials that penetrate into the central nervous system as the microscopic electrode shafts of the neural prostheses interact with neural and other tissues on a cellular and molecular level. In order to achieve tight coupling between these implanted microelectrodes and the target neural substrate, this interaction must be understood and controlled. This contract supported research will study these interactions with a long-term goal of rationally designing microelectrode surfaces to promote specific tissue interactions. The efficiency of these microelectrodes depends on the micro environment around stimulating sites. The surface of the microelectrodes and the proteins that adsorb to this surface have a major impact on the way in which different cell populations react to the implant. Neural growth cones are sent out from many neurons around a microelectrode following implantation. With appropriate surfaces it may be possible to get selected neurons to send processes directly to the microelectrodes. This study will investigate cellular and molecular responses to specific surface modifications of silicon microelectrodes. Personnel with established expertise in cell biology and surface science are needed. It is anticipated that one award will be made for a period of three years. Award is anticipated for September 1994. INQUIRIES This is not a Request for Proposals (RFP). RFP NIH-NINDS-94-04 will be issued on or about February 1, 1994 with proposals due on April 4, 1994. To receive a copy of the RFP, submit a written request along with two self-addressed mailing labels to: Laurie Leonard Contracts Management Branch National Institute of Neurological Disorders and Stroke Federal Building, Room 901 7550 Wisconsin Avenue Bethesda, MD 20892 ATTN: RFP NIH-NINDS-94-04 All responsible sources shall be considered by the agency. .
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