NIH GUIDE, Volume 23, Number 1, January 7, 1994


P.T. 34


  Tissue Culture 

  Biochemical Markers 


  Biology, Cellular 

National Cancer Institute

The Division of Cancer Prevention and Control, National Cancer

Institute (NCI), in its annual requirement to seek new sources, is

soliciting proposals for the Early Detection Research Network (EDRN)

to increase the number of Master Agreement (MA) Holders originally

awarded under MAA No. NCI-CN-15340-04. Current MA Holders for this

program are not required to submit a proposal.  The Master Agreement

Announcement (MAA) is issued to solicit MA holders who have knowledge

in establishing a biorepository of normal premalignant and malignant

tissues by collecting and storing tissues and associated fluids to

identify potential cellular and molecular markers for early

detection.  The project will focus on tissues of the colon and

rectum, lung, prostate, and urinary bladder.  There will be an

associated database with demographic information, exposure to

potential carcinogens, and risk factors on the subjects from whom

specimens have been obtained; and expertise in conducting cellular

and molecular studies on these tissues with the goal of developing

new procedures assessing the sequence of genetic alterations in

protooncogenes, analyzing allelic deletions of suppressor genes,

identifying activated oncogenies, identifying oncogene products

suitable for evaluating neoplastic progression, and developing

cellular and molecular markers that will identify individuals who are

at high risk of cancer.


Requests for this solicitation must be in writing and reference MAA

No. NCI-CN-45580-63.  The Master Agreement Announcement (MAA) is now

available and responses will be due approximately COB January 28,

1994.  Requests are to be addressed to:

Ms. Tina Huyck

Research Contracts Branch, PCCS

National Cancer Institute

Executive Plaza South, Room 635

Bethesda, MD  20892

Telephone:  (301) 496-8603


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