APPLICATION OF DATA ON THE HLA SYSTEM TO THE DEVELOPMENT ANDIMPROVEMENT OF VACCINES AND INFLUENCE OF HLA AND OTHER GENES ON RESPONSE TO VACCINES NIH GUIDE, Volume 23, Number 1, January 7, 1994 RFP AVAILABLE: BAA NIH-NIAID-DAIT/DMID-94-30 P.T. 34 Keywords: Vaccine National Institute of Allergy and Infectious Diseases The Genetics and Transplantation Branch of the Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, promotes and supports research leading to a better understanding of the HLA system, the human major histocompatibility system, including the identification, mapping, and regulation of the HLA genes, the structure and function of the products of the HLA genes, and the role of the HLA system in regulating immune responses in health and disease. The focus of Part I of this Broad Agency Announcement is on basic research that will serve to acquire the data necessary for developing new safe and effective vaccines and for improving existing vaccines, for developing improved methods for isolating, characterizing, and assessing the immunogenic potential of HLA-bound peptides of infectious agents, for developing improved methods for modifying peptides and screening their potential for use in vaccines, for defining the mechanisms underlying regulation of the response to infection and vaccination by the HLA system, and to acquire knowledge about the factors governing the interactions between peptide and HLA molecules and between T cell antigen receptors and HLA-peptide complexes. Part II of this Broad Agency Announcement invites offerors to submit proposals for conducting population research on the role of products of HLA, T cell receptor, immunoglobulin, cytokine, complement, and other genes, in responses to immunization. BAA NIH-NIAID-DAIT/DMID-94-30 will be available on or about January 03, 1993, and proposals will be due approximately March 8, 1994. It is anticipated that more than one cost-reimbursement contract covering one or more categories listed under the Research and Technical Objectives will be awarded for a period up to five years. This advertisement does not commit the government to award a contract. INQUIRIES To receive a copy of this RFP, please supply two self-addressed mailing labels. All inquiries must be in writing and addressed to the office below: Rosemary McCabe Hamill Contracting Officer National Institute of Allergy and Infectious Diseases Contracts Management Branch Solar Building, Room 3C07 6003 Executive Boulevard Bethesda, MD 20892 .
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