AVAILABILITY OF HUMAN LIVER FOR SCIENTIFIC INVESTIGATION NIH GUIDE, Volume 22, Number 45, December 17, 1993 P.T. 34 Keywords: Organs+ Pathophysiology National Institute of Diabetes and Digestive and Kidney Diseases The Liver Tissue Procurement and Distribution System (LTPADS) is an NIH service contract to obtain human liver from regional centers for distribution to scientific investigators throughout the United States. These regional centers have active liver transplant programs with human subjects approval to provide portions of the resected pathologic liver for which the transplant is performed. Human pathologic liver prepared according to the investigator's specifications provides the opportunity to verify if animal liver investigations are relevant to human liver pathophysiology. The preparation of these livers has been excellent for the usual molecular biologic techniques. Therefore, we are primarily interested in soliciting proposals from investigators interested in studying pathologic liver specimens. Frozen tissue is available from subcontractors for the usual forms of childhood and adult cirrhosis, fulminant liver failure, chronic rejection, and certain inborn errors of metabolism. A limited supply of "normal" liver specimens may also be requested but the turn around time for completion of large requests for "normal" liver is much longer than the most pathologic liver specimens. INQUIRIES For further information and proposal forms for interested investigators can be obtained from: Harvey L. Sharp, M.D. Principal Investigator, LTPADS c/o Elizabeth Webster Box 279 UMHC University of Minnesota Hospitals Minneapolis, MN 55455 Telephone: (612) 624-1133 .
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