NIH GUIDE, Volume 22, Number 45, December 17, 1993

P.T. 34




National Institute of Diabetes and Digestive and Kidney Diseases

The Liver Tissue Procurement and Distribution System (LTPADS) is an

NIH service contract to obtain human liver from regional centers for

distribution to scientific investigators throughout the United

States.  These regional centers have active liver transplant programs

with human subjects approval to provide portions of the resected

pathologic liver for which the transplant is performed.  Human

pathologic liver prepared according to the investigator's

specifications provides the opportunity to verify if animal liver

investigations are relevant to human liver pathophysiology.  The

preparation of these livers has been excellent for the usual

molecular biologic techniques.  Therefore, we are primarily

interested in soliciting proposals from investigators interested in

studying pathologic liver specimens.  Frozen tissue is available from

subcontractors for the usual forms of childhood and adult cirrhosis,

fulminant liver failure, chronic rejection, and certain inborn errors

of metabolism.  A limited supply of "normal" liver specimens may also

be requested but the turn around time for completion of large

requests for "normal" liver is much longer than the most pathologic

liver specimens.


For further information and proposal forms for interested

investigators can be obtained from:

Harvey L. Sharp, M.D.

Principal Investigator, LTPADS

c/o Elizabeth Webster

Box 279 UMHC

University of Minnesota Hospitals

Minneapolis, MN  55455

Telephone:  (612) 624-1133


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