ANIMAL MODELS FOR CHRONIC LYME DISEASE

NIH GUIDE, Volume 22, Number 44, December 10, 1993



BAA AVAILABLE:  NIH-NIAID-DMID-94-31



P.T. 34



Keywords:

  Microbiology 

  Disease Model 



National Institute of Allergy and Infectious Diseases



The Bacteriology and Mycology Branch of the Division of Microbiology

and Infectious Diseases, National Institute of Allergy and Infectious

Diseases (NIAID), promotes and supports research in the biochemistry,

physiology, and genetics of bacteria and fungi, especially studies

involving medically relevant species.  The focus of this Broad Agency

Announcement (BAA) is on basic research that will serve to advance

clinical protocols for treating or preventing chronic Lyme disease in

human populations.  Examples of such research include:  the

development of an experimental animal model for late stage Lyme

disease that exhibits consistent development of histologically

demonstrable arthritis, or neurological symptoms characteristic of

chronic Lyme disease in an immunologically intact animal; the

development of an animal model demonstrating immune responses

reflecting the complexity of those observed in human disease; and the

development of an animal model examining the role of the skin in

facilitating infection, dissemination and persistence of spirochetes,

including host-bacterium factors that allow spirochete persistence in

the skin in the absence of apparent host immune responses, the

intracellular or extracellular location of spirochetes in the skin

and other immunologically privileged sites, and the affects of

spirochete persistence on determinations of therapeutic endpoints.



BAA NIH-NIAID-DMID-94-31 will be available on or about December 27,

1993, and proposals will be due approximately February 28, 1994.  It

is anticipated that one or more cost-reimbursement contracts covering

one or more categories listed under the Research and Technical

Objectives will be awarded for a period of up to four years.  Any

responsible offeror may submit a proposal that will be considered by

the Government.



INQUIRIES



To receive a copy of this BAA, supply this office with a self-

addressed mailing label.  All inquires must be in writing and

addressed to:



Carl R. Henn

Contracts Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

Bethesda, MD  20892



.

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