NIH GUIDE, Volume 22, Number 43, November 26, 1993


P.T. 34


  Cardiovascular Diseases 



National Heart, Lung, and Blood Institute

The National Heart, Lung, and Blood Institute (NHLBI) is soliciting

proposals for clinical centers to participate in a multicenter

clinical trial designed to develop and evaluate various intervention

approaches delivered in health-care settings as to their

effectiveness in increasing and maintaining physical activity and

cardiorespiratory fitness among sedentary men and women at elevated

risk of coronary heart disease (CHD) by blood pressure (BP) or

lipoprotein criteria.  The study will also examine the

cost-effectiveness of the various intervention approaches as well as

the magnitude of effects on BP, lipoproteins, and weight and the

long-term maintenance of those effects.

Approximately three clinical center contracts will be awarded.  Each

clinic will be responsible for recruiting approximately 270 adult

participants with elevated BP or atherogenic lipid profile, who are

sedentary, for randomization into one of three intervention groups

and one comparison group.  This will be a five-year study with a

projected award date of September 30, 1994.  The primary study

outcomes will be cardiorespiratory fitness (i.e., maximum oxygen

uptake) and physical activity (frequency, intensity, duration, and

estimated caloric expenditure).  Appropriate settings for the

clinical centers are health-care sites that provide primary care,

such as physician's offices, health maintenance organizations,

hospital outpatient clinics, and community health centers.  Research

clinics may be appropriate if shown to be applicable to the delivery

of primary care.  Because of the need for scientifically comparable

data in a defined population and relevance to the U.S. health care

system, offerors other than U.S. institutions will not be considered.

This procurement is open to all offerors who meet the determination

of responsibility as defined by FAR 9.104.  Request for Proposal

(RFP) No. NHLBI-HC-94-06 will be available on approximately November

26, 1993.  Proposals will be due on March 21, 1994.


All requests for this RFP must be submitted in writing to the address

listed below; telephone requests will not be accepted.  Written

requests must reference RFP No. NHLBI-HC-94-06 and include three

self-addressed mailing envelopes.

John C. Taylor, Contracting Officer

National Heart, Lung, and Blood Institute

7550 Wisconsin Avenue

Federal Building, Room 200

Bethesda, MD  20892

Telephone:  (301) 496-9655


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