RESYNTHESIS OF COMPOUNDS FOR SCREENING NIH GUIDE, Volume 22, Number 30, August 20, 1993 RFP AVAILABLE: NCI-CM-47007-29 P.T. 34 Keywords: Antivirals AIDS Chemistry, Organic Chemical Synthesis National Cancer Institute The Drug Synthesis and Chemistry Branch (DS&CB) of the Developmental Therapeutics Program (DTP) of the Division of Cancer Treatment (DCT) of the National Cancer Institute (NCI) is seeking Contractors with established expertise in the field of synthesis of organic and inorganic compounds to prepare those deemed of interest to the program for evaluation as antitumor and AIDS-antiviral agents. The primary focus will be to synthesize samples of compounds, generally identified from literature sources, that have been designated of interest to the DTP drug development program and which are not available from the original sources. Compounds may be required for either primary screening or follow-up testing in the anticancer and/or anti-HIV programs. Compounds assigned for synthesis will include, but not be limited to, carbocycles, heterocycles typically containing nitrogen, oxygen, and sulfur, carbohydrates, nucleosides, and metal coordination complexes. Detailed experimental procedures obtained from the literature will be available for the majority of the assignments. Some development on synthetic methods may be required in those cases where no such procedures are available or when the published methods prove unreliable in practice. The quantities of compounds to be prepared will vary widely, but will usually be in the range from 0.1 to 5 grams. All synthesized compounds submitted to the DS&CB (at least 15 to 20 target compounds per year per contract) will be characterized as to identity and purity. Each Contractor must have available a fully operational facility including all necessary equipment and instrumentation needed to perform for all aspects of the contract. The NCI signs legally binding agreements with some suppliers (often pharmaceutical or chemical companies) which state that all information on compounds donated by those suppliers will be held confidential. The occasion may arise whereby the successful offeror will be assigned such a confidential compound as a synthesis or modification target. If the Contractor were a chemical pharmaceutical company, they could gain valuable data on confidential new lead compounds. The NCI believes that in order to honor the confidentiality agreement with suppliers and in order to avoid any chance of transmitting privileged data to a competitor, pharmaceutical and chemical companies must be excluded from the competition. A pharmaceutical or chemical company is defined as an organization which sells drugs and/or chemicals to the general public for profit. NOTE: Two related RFPs are currently available. It is anticipated that multiple incrementally funded contracts will be awarded for a period of five years beginning on or about September 1, 1994. RFP No. NCI-CM-47007-29, Resynthesis of Compounds for Screening, is an open competition. RFP No. NCI-CM-47015-29, Resynthesis of Compounds for Screening by Small Business, is a 100% set-aside for small business. The Standard Industrial Code (SIC) for the small business set-aside is 8731 (500 employees). Offerors who qualify as a small business are encouraged to submit proposals under both RFPs; however, not more than one award of the available awards (under both RFPs) will be made to any single offering organization. INQUIRIES These projects represent a recompetition of contracts with New Mexico State University, N01-CM-17528, Research Triangle Institute, N01-CM-17568, and Starks Associates, N01-CM-17517. Both RFPs will be issued on or about September 20, 1993. Proposals will be due on November 5, 1993. Requests for the RFP may be made by written request to: Clyde Williams, Contracting Officer Research Contracts Branch, TCS National Cancer Institute Executive Plaza South, Room 603 Bethesda, MD 20892 Telephone: (301) 496-8620 Collect calls will not be accepted. .
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