REHABILITATION AND PSYCHOSOCIAL RESEARCH IN YOUNGER WOMEN WITH BREASTCANCER



NIH GUIDE, Volume 22, Number 26, July 23, 1993



RFA AVAILABLE:  CA/HD-93-033



P.T. 34



Keywords:

  Cancer/Carcinogenesis 

  Rehabilitation/Therapy, Emotional 

  Rehabilitation/Therapy, Physical 

  Social Psychology 



National Cancer Institute

National Institute of Child Health and Human Development



Letter of Intent Receipt Date:  August 31, 1993

Application Receipt Date:  November 9, 1993



THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS

ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION.

APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES,

BELOW.



PURPOSE



The Division of Cancer Prevention and Control (DCPC), National Cancer

Institute (NCI) and the National Center for Medical Rehabilitation

Research (NCMRR), National Institute of Child Health and Human

Development (NICHD) invite investigator-initiated grant applications

for research directed at decreasing the medical and psychological

morbidity and disability associated with breast cancer diagnosis and

treatment in younger women.  Applications must develop and test

interventions that address health issues, psychosocial problems, and

potential disability faced by women diagnosed with breast cancer during

early adult life.



HEALTHY PEOPLE 2000



The Public Health Service (PHS) is committed to achieving the health

promotion and disease prevention objectives of "Healthy People 2000,"

a PHS-led national activity for setting priority areas.  This RFA,

Rehabilitation and Psychosocial Research in Younger Women with Breast

Cancer, is related to the priority area of cancer.  Potential

applicants may obtain a copy of "Healthy People 2000" (Full Report:

Stock No. 017-001-00474-0 or Summary Report:  Stock No.

017-001-00473-1) through the Superintendent of Documents, Government

Printing Office, Washington, DC 20402-9325, telephone 202-783-3238.



ELIGIBILITY REQUIREMENTS



Applications may be submitted by domestic and foreign for-profit and

non-profit organizations, public and private, such as universities,

colleges, hospitals, laboratories, units of State and local

governments, and eligible agencies of the Federal government.

Applications from minority individuals and women are encouraged.



MECHANISM OF SUPPORT



This RFA will use the National Institutes of Health (NIH) individual

research project grant (R01).  Responsibility for the planning,

direction, and execution of the proposed project will be solely that of

the applicant.  The total project period for applications submitted in

response to this RFA may not exceed four years.  The anticipated award

date is July 1, 1994.  Because the nature and scope of research

proposed in response to this RFA may vary, it is anticipated that the

size of award will vary also.  The anticipated amount of the direct

costs per award will vary from $100,000 to $400,000.  This RFA is a

one-time solicitation.  Future unsolicited competitive continuation

applications will compete with all investigator-initiated and be

reviewed according to the customary NIH peer review procedures.



FUNDS AVAILABLE



Total costs of $2,400,000 per year for four years will be committed to

specifically fund applications that are submitted in response to this

RFA.  It is anticipated that four to seven awards will be made.



RESEARCH OBJECTIVES



The goal of this RFA is to enhance the quality of life of younger women

with breast cancer.  Objectives are to:  (1) identify and describe the

medical, psychosocial, and disability-related sequelae of breast cancer

diagnosis and treatment in younger women and (2) develop and test

interventions directed at the specific problems associated with breast

cancer diagnosis and treatment in this age group.



Projects will develop, implement, and evaluate interventions directed

at problems including (1) medical sequelae of therapy; (2) body image,

sexuality, and reproductive issues; (3) interpersonal and family

relationships; (4) concrete needs; (5) education, career

development/advancement, employment, and insurance; (6) living with

medical uncertainty; (7) special needs of younger patients during

periods of progressive disease and/or terminal care; or (8) the impact

of ethnic and cultural factors on issues listed above.  Younger women

are defined by chronologic age (<50 years) or by menopausal status

(pre- and/or peri-menopausal) at diagnosis and study entry, depending

on the study intervention.  Formal evaluation of efficacy is required,

with outcome variables of health-related quality of life (QOL), domains

reflecting medical and psychological morbidity, and relevant aspects of

disability, such as personal productivity and community participation.

A multidisciplinary research approach is recommended.



STUDY POPULATIONS



SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL

RESEARCH STUDIES



For projects involving clinical research, NIH requires applicants to

give special attention to the inclusion of women and minorities in

study populations.  If women and minorities are not included in the

study populations for clinical studies, a specific justification for

this exclusion must be provided.  Applications without such

documentation will not be accepted for review.



LETTER OF INTENT



Prospective applicants are asked to submit, by August 31, 1993, a

letter of intent that includes a descriptive title of the proposed

research; the name, address, telephone and FAX numbers of the Principal

Investigator; the  identities of other key personnel and the

participating institutions; and the number and title of the RFA in

response to which the application may be submitted.  Although a letter

of intent is not required, is not binding, and does not enter into the

review of a subsequent application, it contains information that is

helpful in planning for the review.  The letter of intent allows NCI

and NICHD staff to estimate the potential review workload and helps to

avoid conflict of interest in the review.  The letter of intent is to

be sent to Dr. Susan G. Nayfield at the address listed under INQUIRIES.



APPLICATION PROCEDURES



The research grant application form PHS 398 (rev. 9/91) is to be used

in applying for these grants.  The application package is available at

most institutional offices of sponsored research; from the Office of

Grants Information, Division of Research Grants, National Institutes of

Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone

301-435-0714; and from the NCI Program Director listed under INQUIRIES.

Applications must be received by close of business November 9, 1993.



REVIEW CONSIDERATIONS



Applications responsive to this competitive solicitation will be

reviewed according to the following criteria:



(1) scientific merit, clinical significance and originality, and

feasibility of the proposed research;



(2) appropriateness and adequacy of the research approach and proposed

methodology to the goal and objectives of the RFA;



(3) appropriateness of the study population and inclusion of or

direction of research toward special populations;



(4) feasibility of interventions for the community setting;



(5) qualifications and experience of the Principal Investigator and

staff;



(6) use of multidisciplinary expertise from related health care

specialty fields



(7) adequacy of facilities and resources; and



(8) adequacy of protection from hazardous or unethical research

procedures.  Scientific merit, availability of funds, and program

balance among research areas will be considered in funding decisions.



INQUIRIES



Written and telephone requests for the RFA and the opportunity to

clarify any issues or questions from potential applicants are welcome.

Direct requests for the RFA, inquiries regarding programmatic issues,

and address the letter of intent to:



Susan G. Nayfield, M.D., M.Sc.

Division of Cancer Prevention and Control

National Cancer Institute

Executive Plaza North, Room 300-F

Bethesda, MD  20892

Telephone:  (301) 496-8541



Louis A. Quatrano, Ph.D.

National Center for Medical Rehabilitation Research

National Institute of Child Health and Human Development

6100 Executive Boulevard, Room 2A-0

Bethesda, MD  20892

Telephone:  (301) 402-2242

FAX:  (301) 402-0832



Direct inquiries regarding fiscal matters to:



Ms. Victoria Price

Grants Administration Branch

National Cancer Institute

Executive Plaza South, Suite 243

Bethesda, MD  20892

Telephone:  (301) 496-7800, Ext. 52



AUTHORITY AND REGULATIONS



This program is described in the Catalog of Federal Domestic Assistance

No. 93.399, Cancer Control Research.  Awards are made under the

authorization of the Public Health Service Act, Title IV, Part A

(Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and

285) and administered under PHS grants policies and Federal Regulations

42 CFR 52 and 45 CFR Part 74.  This program is not subject to the

intergovernmental review requirements of Executive Order 12372 or

Health Systems Agency review.



.


Return to 1993 Index

Return to NIH Guide Main Index


Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS)
  USA.gov - Government Made Easy


Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.