CORRELATES OF HIV IMMUNE PROTECTION LABORATORY

NIH GUIDE, Volume 22, Number 25, July 16, 1993



RFP AVAILABLE:  NIAID-DAIDS-94-12



P.T.





Keywords:



National Institute of Allergy and Infectious Diseases



The National Institute of Allergy and Infectious Diseases (NIAID),

NIH has a requirement for a Correlates of HIV Immune Protection

Laboratory that will provide extensive, coordinated, in-depth

evaluation of the immunology and/or virology of recipients of

acquired immunodeficiency syndrome (AIDS) vaccine(s) who are not

protected against HIV-1.  Vaccinees or subjects in natural history

cohorts who are apparently exposed to, but not infected by, HIV and

when available, their infected partners, also will be included in

these extensive evaluation studies.  Control subjects will include

infected placebo recipients and uninfected vaccine responders who may

have been exposed to HIV during the same or parallel vaccine studies,

recent seroconverters, and HIV-infected subjects with evidence of

prolonged asymptomatic periods following infection who have been

identified in natural history cohorts.  Therefore, this proposed

Contract will establish the Correlates of HIV Immune Protection

Laboratory, which will provide extensive, in-depth evaluation of the

humoral and cellular immune responses of vaccinee and cohort study

subjects and controls.  In addition, from infected subjects, this

laboratory will isolate and characterize the genotype and both the

serological and biological phenotype of infecting HIV.



This contract is intended to support the NIAID mission of development

and clinical testing of AIDS vaccines.  It is anticipated that a

single contract will be awarded to carry out highly coordinated

immunological, virological, and molecular biological assessments.  It

is further anticipated that a consortium of laboratories with the

distinct expertise will be required for the successful completion of

the different technical tasks.



This is an announcement for an anticipated Request for Proposals

(RFP).  The issuance of RFP No. NIH-NIAID-DAIDS-94-12 will be on or

about August 15, 1993 and proposals will be due by the close of

business on November 15, 1993.  It is anticipated that one contract

will be awarded to carry out highly coordinated immunological,

virological, and molecular virological assessments as a result of

this solicitation.  It is expected that the contract will have a

five-year period of performance and a completion type cost-

reimbursement contract is anticipated.



INQUIRIES



Requests for the RFP are to be directed in writing to:



Mr. Lawrence Butler

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

6003 Executive Boulevard

Bethesda, MD  20892



(use Rockville, Maryland 20852 for overnight mail service)



Please provide this office with three self-addressed mailing labels.

Telephone inquiries will not be honored and all inquiries must be in

writing.  A short-form version of the RFP will be provided, which

includes the Statement of Work and the Evaluation Criteria to be used

for selection of the awardee.  All proposals from responsible sources

will be considered by the NIAID.  This advertisement does not commit

the Government to award a contract.  No collect calls will be

accepted.



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