STUDIES OF CHEMICAL DISPOSITION IN MAMMALS NIH Guide, Volume 22, Number 15, April 16, 1993 RFP AVAILABLE: NIH-ES-93-27 P.T. 34 Keywords: Environmental Health Bioassay Toxicology National Institute of Environmental Health Sciences The purpose of this project is to obtain detailed chemical disposition data from approximately three to five studies per year of selected environmental contaminants or model compounds per year. Most of these studies will be required in laboratory rats and/or mice; however, some studies may be required in other laboratory animals (rodents or dogs). Offerors should note that in year one and in subsequent years, most studies will involve rats (Fisher 344) and/or mice (B6C3F1). For costing purposes offerors are to include costs for one study using purebred beagle dogs purchased from a commercial breeder of laboratory animals in year one, only. In addition, an estimated one study per year may be required to investigate the comparative metabolism of chemicals in human and rat liver slices in vitro. Most studies will address the disposition of organic chemicals or environmental contaminants; however, studies of inorganic compounds may also be requested. Individual studies may vary in complexity from preliminary investigations of chemical absorption to detailed studies of all phases of chemical disposition, toxicokinetics, and metabolism. The immediate goal of these studies is to determine more accurately the doses for NTP bioassay studies. The long-range goal is the accumulation of data what will permit a better assessment of structure-activity relationships chemical absorption, metabolism and disposition in laboratory animals and in liver slices in vitro and to better interpret the significance of these data to man. This project will cover a five year period. The Government estimates that the project will require approximately 1.5 professional person years and 3.0 technical person years per contract year. INQUIRIES Requests should reference RFP No. NIH-ES-93-27 and are to be forwarded to: Marilyn B. Whaley, Contract Specialist Contracts and Procurement Management Branch, OM National Institute of Environmental Health Sciences 79 T.W. Alexander Drive, 4401 Building P.O. Box 12874 Research Triangle Park, NC 27709 Telephone: (919) 541-0416 FAX: (919) 541-2712 .
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