NIH Guide, Volume 22, Number 13, April 2, 1993


P.T. 34


  Transplantation of Organs 

  Biology, Cellular 

  Biology, Molecular 

  Transplantation Immunology 

National Institute of Allergy and Infectious Diseases

The Basic Immunology and the Genetics and Transplantation Branches of

the Division of Allergy, Immunology and Transplantation (DAIT),

National Institute of Allergy and Infectious Diseases (NIAID), promote

and support research leading to a better understanding of the

development of the immune system and the fundamental cellular and

molecular biology of immune responses in health and disease.  The focus

of the Broad Agency Announcement (BAA) is on basic research that will

serve to acquire the data necessary for advancing clinical protocols

for successful bone marrow transplantation and effective therapeutic

treatment for GVHD.  Offerors are encouraged to submit proposals

relevant to any one of the general areas of research interest described

in the BAA in accordance with the instructions in the BAA.  Topics

include:  Development of an experimental model for bone marrow

transplantation using isolated hematopoietic stem cells; development of

in vitro culture methods of stem cells to study the cellular and

molecular nature of purified stem cells with the ultimate goal of ex

vivo expansion (self renewal); establishment of pre and/or post

transplant conditioning regimens for BM engraftment; characterization

of immunological mechanisms responsible for failure or rejection of

transplanted BM; and development of prophylactic conditioning or

therapeutic regimens for GVHD.

Several contract awards are anticipated as a result of this

announcement.  It is anticipated that the awards will be made on a cost

reimbursement basis over a multi-year period.  Awards will be subject

to DHHS regulations regarding the use of laboratory animals and/or

human subjects in research.  The issuance of the BAA was February 22,

1993 and proposals are due on May 10, 1993 at 4:00 p.m.


To receive a copy of the BAA, submit a written request along with two

self-addressed mailing labels to:

Rosemary McCabe Hamill, Contracting Officer

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

6003 Executive Boulevard

Bethesda, MD  20892

Telephone inquiries will not be honored and all inquiries must be in

writing.  Any responsible offeror may submit a proposal that will be

considered by the Government.  This advertisement does not commit the

Government to award a contract.


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