ACQUISITION OF DATA FOR ESTABLISHING AND IMPROVING STRATEGIES FORTRANSPLANTATION OF BONE MARROW NIH Guide, Volume 22, Number 13, April 2, 1993 BAA AVAILABLE: NIH-NIAID-DAIT-BAA-93-26 P.T. 34 Keywords: Transplantation of Organs Biology, Cellular Biology, Molecular Transplantation Immunology National Institute of Allergy and Infectious Diseases The Basic Immunology and the Genetics and Transplantation Branches of the Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), promote and support research leading to a better understanding of the development of the immune system and the fundamental cellular and molecular biology of immune responses in health and disease. The focus of the Broad Agency Announcement (BAA) is on basic research that will serve to acquire the data necessary for advancing clinical protocols for successful bone marrow transplantation and effective therapeutic treatment for GVHD. Offerors are encouraged to submit proposals relevant to any one of the general areas of research interest described in the BAA in accordance with the instructions in the BAA. Topics include: Development of an experimental model for bone marrow transplantation using isolated hematopoietic stem cells; development of in vitro culture methods of stem cells to study the cellular and molecular nature of purified stem cells with the ultimate goal of ex vivo expansion (self renewal); establishment of pre and/or post transplant conditioning regimens for BM engraftment; characterization of immunological mechanisms responsible for failure or rejection of transplanted BM; and development of prophylactic conditioning or therapeutic regimens for GVHD. Several contract awards are anticipated as a result of this announcement. It is anticipated that the awards will be made on a cost reimbursement basis over a multi-year period. Awards will be subject to DHHS regulations regarding the use of laboratory animals and/or human subjects in research. The issuance of the BAA was February 22, 1993 and proposals are due on May 10, 1993 at 4:00 p.m. INQUIRIES To receive a copy of the BAA, submit a written request along with two self-addressed mailing labels to: Rosemary McCabe Hamill, Contracting Officer Contract Management Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 3C07 6003 Executive Boulevard Bethesda, MD 20892 Telephone inquiries will not be honored and all inquiries must be in writing. Any responsible offeror may submit a proposal that will be considered by the Government. This advertisement does not commit the Government to award a contract. .
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