PREPARATION OF IMMUNOCONJUGATES

NIH GUIDE, Volume 22, Number 9, March 5, 1993



MAA AVAILABLE:  NCI-CM-37843-37



P.T. 34



Keywords:

  Cancer/Carcinogenesis 



National Cancer Institute



Master Agreement Announcement (MAA) No. NCI-CM-37843-37, as published

in the NIH Guide for Grants and Contracts, Vol. 22, No. 7, February

19, 1993, is amended to read as follows.  This project was originally

synopsized as a MAA No. NCI-CM-27731.  The purpose of this

procurement is to prepare preclinical and clinical grade monoclonal

antibodies, antibody fragments, peptides, and/or other genetically

engineered targeting molecules that are linked to chelating agents.

The NCI will provide purified targeting molecules to the contractor

for chemical conjugation to chelating agents using procedures that

have either appeared in the peer reviewed literature or have been

developed by the NCI.  Proprietary technology developed by the

offeror to prepare the desired immunoconjugates would prepare

radioimmunoconjugates for both preclinical and clinical applications.

All synthetic and purification procedures will be performed under

Good Laboratory Procedures (GLP) and/or Good Manufacturing Practice

(GMP).  It is anticipated that the offeror will be required to

prepare approximately 10-1000 mg of each immunoconjugate.  The

offeror will evaluate these immunoconjugates for purity, stability,

immunoreactivity, and other criteria specified by the NCI.  One or

more awards may be made to qualified offerors responding to the RFP.



INQUIRIES



The amended MAA No. NCI-CM-37843-37 is now available and responses

will be due on or about April 15, 1993.  To obtain a copy of the

Master Agreement Announcement, call or write:



Patricia Lightner or Dorothy M. Coleman

Treatment Contracts Section, Research Contracts Branch

National Cancer Institute

Executive Plaza South, Room 603

Bethesda, MD  20892

Telephone:  (301) 496-8620

No collect calls will be accepted.



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