ISOLATION AND CHARACTERIZATION OF MHC-BOUND SELF PEPTIDES INAUTOIMMUNE DISEASE



NIH GUIDE, Volume 22, Number 7, February 19, 1993



BAA/RFP AVAILABLE:  NIH-NIAID-DMID-94-15



P.T. 34



Keywords:

  Autoimmunity 

  Peptides 

  Bioassay 

  Pathogenesis 



National Institute of Allergy and Infectious Diseases



The Division of Microbiology and Infectious Diseases Program of the

National Institute of Allergy and Infectious Diseases (NIAID), has a

requirement for Isolation and Characterization of MHC-Bound Self

Peptides in Autoimmune Disease.  The Clinical Immunology Branch,

DMID, NIAID, promotes and supports research leading to the

elucidation of the immune mechanisms in disease and in the

application of this basic knowledge to the development of new forms

of diagnosis and treatment for immunologic diseases.  The foci of

this Broad Agency Announcement (BAA) are:  Research Area A -

Isolation, biochemical characterization, and detailed analysis of

biological activity of MHC-bound self-peptides linked to the

pathogenesis of autoimmune disease and Research Area B - Development

and implementation of new experimental systems to test pathogenicity

of human lymphoid cells reactive with self-peptides.  This NIAID

sponsored project will take approximately five years to complete.



A cost-reimbursement contract is anticipated.  It is anticipated that

up to five awards will be made.  This is an announcement for an

anticipated Broad Agency Announcement (BAA)/Request for Proposal

(RFP).  BAA/RFP No. NIH-NIAID-DMID-94-15 will be issued on or about

February 19, 1993, with a closing date tentatively set for July 6,

1993.



INQUIRIES



To receive a copy of the RFP, supply this office with two self-

addressed mailing labels.  All responsible sources may submit a

proposal that will be considered.  Requests for the RFP may be

directed in writing to:



Anthony Murray, Contracting Officer

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

6003 Executive Boulevard

Bethesda, MD  20892



This advertisement does not commit the Government to award a

contract.



.

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