IN VITRO ANTIVIRAL SCREEN FOR HEPATITIS VIRUSES NIH GUIDE, Volume 22, Number 6, February 12, 1993 RFP AVAILABLE: NIH-NIAID-DMID-94-03 P.T. 34 Keywords: Screening of Drugs/Agents Viral Studies (Virology) Enzymes National Institutes of Allergy and Infectious Diseases The Enteric Diseases Branch, National Institute of Allergy and Infectious Diseases (NIAID), seeks investigators to perform in vitro screening for compounds for their ability to inhibit the growth, replication, or enzymatic processes of hepatitis viruses, specifically the hepadnaviruses like hepatitis B virus and hepatitis C virus. The contractor will provide the necessary equipment, personnel, facilities, and materials to screen 200 compounds annually. The contractor will be responsible for determining a compound's antiviral activity, cytotoxicity, and selective index. Research on the development of improved screening methodology, basic studies on mechanism of action, and studies of efficacy of drug combinations will be encouraged as an adjunct to the primary antiviral evaluation. Request for Proposals (RFP) NIH-NIAID-DMID-94-03 is now available. Responses are due by close of business on March 25, 1993. It is anticipated that one cost-reimbursement, completion, contract covering the virus classes individually will be awarded for a period of five years. Any responsible offeror may submit a proposal that will be considered by the government. INQUIRIES To receive a copy of this RFP, supply this office with two self-addressed mailing labels. Telephone inquiries will not be honored and all inquiries must be in writing and addressed to: Frank Murphy, Contract Specialist National Institute of Allergy and Infectious Diseases 6003 Executive Boulevard Solar Building, Room 3C07 Bethesda, MD 20892 This advertisement does not commit the government to award a contract. .
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