NIH GUIDE, Volume 22, Number 6, February 12, 1993


P.T. 34


  Screening of Drugs/Agents 

  Viral Studies (Virology) 


National Institutes of Allergy and Infectious Diseases

The Enteric Diseases Branch, National Institute of Allergy and

Infectious Diseases (NIAID), seeks investigators to perform in vitro

screening for compounds for their ability to inhibit the growth,

replication, or enzymatic processes of hepatitis viruses,

specifically the hepadnaviruses like hepatitis B virus and hepatitis

C virus.  The contractor will provide the necessary equipment,

personnel, facilities, and materials to screen 200 compounds

annually.  The contractor will be responsible for determining a

compound's antiviral activity, cytotoxicity, and selective index.

Research on the development of improved screening methodology, basic

studies on mechanism of action, and studies of efficacy of drug

combinations will be encouraged as an adjunct to the primary

antiviral evaluation.

Request for Proposals (RFP) NIH-NIAID-DMID-94-03 is now available.

Responses are due by close of business on March 25, 1993.  It is

anticipated that one cost-reimbursement, completion, contract

covering the virus classes individually will be awarded for a period

of five years.  Any responsible offeror may submit a proposal that

will be considered by the government.


To receive a copy of this RFP, supply this office with two

self-addressed mailing labels.  Telephone inquiries will not be

honored and all inquiries must be in writing and addressed to:

Frank Murphy, Contract Specialist

National Institute of Allergy and Infectious Diseases

6003 Executive Boulevard

Solar Building, Room 3C07

Bethesda, MD  20892

This advertisement does not commit the government to award a



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