IN VITRO ANTIVIRAL SCREEN FOR HERPES AND RESPIRATORY VIRUSES NIH GUIDE, Volume 22, Number 1, January 8, 1993 RFP AVAILABLE: NIH-NIAID-DMID-93-07 P.T. 34 Keywords: Viral Studies (Virology) Screening of Drugs/Agents Antivirals Inhibitors National Institute of Allergy and Infectious Diseases The Antiviral Research Branch of the Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), has a requirement for investigators to perform in vitro screening of compounds for their ability to inhibit the growth and/or replication of herpes viruses (HSV, CMV, VZV, EBV) and respiratory viruses (influenza, parainfluenza, respiratory syncytial virus, measles). The contractor(s) will provide the necessary equipment, personnel, facilities, and materials to screen 200 compounds annually. The contractor(s) will be responsible for determining a compound's antiviral activity, cytotoxicity, and selective index. Research on the development of improved screening methodology, studies on mechanism of action, and studies of efficacy of drug combinations will be encouraged as an adjunct to the primary antiviral evaluation. It is anticipated that either one cost-reimbursement, completion, contract covering all virus classes or two cost-reimbursement, completion, contracts covering the virus classes individually will be awarded for a period of five years. This is an announcement for an anticipated Request for Proposals (RFP). RFP NIH-NIAID-DMID-93-07 will be issued on or about December 28, 1992, with a closing date tentatively set for March 5, 1993. INQUIRIES Requests for the RFP are to be directed in writing to: Sara Southard, Contract Specialist, Contract Management Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 3C07 6003 Executive Boulevard Bethesda, MD 20892 To receive a copy of the RFP, supply this office with two self-addressed mailing labels. All responsible sources may submit a proposal that will be considered by the government. This advertisement does not commit the government to award a contract. .
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