CAPABILITY FOR THE CONSTRUCTION OF RECOMBINANT MALARIA VACCINES NIH GUIDE, Volume 21, Number 43, November 27, 1992 RFP AVAILABLE: NIAID-DMID-93-11 P.T. 34 Keywords: Vaccine Peptides Recombinant DNA Bioassay National Institute of Allergy and Infectious Diseases The National Institute of Allergy and Infectious Diseases (NIAID) has a requirement for a malaria vaccine design. This requirement is for a facility and team of scientists to synthesize, using recombinant DNA technology, and to express biological constructs encoding polypeptide products based on malaria antigens. This requirement is part of a cooperative initiative with the Agency for International Development. Respondents must have facilities and equipment to allow the construction of recombinant antigen genes from know sequences and cloned DNA specimens, the efficient expression of polypeptide products of such recombinant gene constructs, and protein purification. Quality control, including assessment of protein purity and immunologic evaluation of synthesized polypeptide products in animal models, must also be a part of the capability. The government will work closely with the contractor in the selection and design of the candidate genes and expression systems. The contractor will also participate and assist in development of Investigational New Drugs (IND) applications. Scaled-up production according to current Good Manufacturing Practices, clinical trials, and aspects of the preclinical evaluation of the polypeptide products of the recombinant genetic constructs, will be conducted at other facilities. Any contract awarded will be subject to DHHS regulations regarding the animal subjects in research. One contract may be awarded as a result of this solicitation. It is expected that the contract will have a three-year period of performance. The issuance of the Requests for Proposals (RFP) will be on or about November 23, 1992 and proposals will be due by the close of business on January 15, 1993. Any responsible offeror may submit a proposal that will be considered by the Government. INQUIRIES To receive a copy of the RFP, provide this office with two self-addressed mailing labels. Requests for the RFP may be directed to: Merilee Rahe-Stoline Contract Specialist, Contract Management Branch National Institute of Allergy and Infectious Diseases 6003 Executive Boulevard, Room 3C07 Bethesda, MD 20892 This advertisement does not commit the Government to award a contract. .
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